I took Tramadol for the first time last week. I was really surprised at the result; it did more than relieve my pain - my fatigue diminished dramatically and my cognition improved significantly - I was definitely thinking much clearer.
Issie believes tramadol has all sorts of other effects including effects on the autonomic nervous system. I'm a believer.
I'm just going to use it sporadically and I look forward to using it again.
See my post re @Remy
I have evolved an observational premise that CFS is an intangible, like a feeling which is biochemical, i.e. in the brain. It’s causes may be close to the psychiatric field, but more tangibly, neurological mechanisms.
I think we all have this dynamic which is so far undiscovered in its piecemeal constituency. It’s like the reaction of a chameleon changing colors. It’s cause, though unknown as yet suggests a psychoactive place in the mind, triggered by stress of some sort, likely inputted through the eyes, whether triggers are physical or mental.
This is a neurological rabbit hole. It is difficult to explore because the science is so esoteric and complicated and neuroscientists have more pressing agendas. I wonder how many of them even take time to consider the nature of CFS relative to their specialized fields. Or, are they even aware of the problem, much of which has neurological correlations?
Many psychoactive drugs already yield dramatic palliative results for the various stages of CFS, e,g. dealing with cognitive issues, crashes and PEM. They, the various rxs can change the course of CFS, maybe not cure it but make it tolerable, doable?
In conclusion, I would raise research appeals around the various neurological camps. This calls for the classic paradigm shift in focus - to research and funding in neuroscience. It seems reasonable that the time is right. Infectious disease stalwarts have for decades beat the same old drums looking for viruses, immune dysfunctions, mitochondrial disorders, and dietary experiments with little to no real effective results, like looking for the lost keys under the lamp posts. Why not work backwards from palliative psychoactive drugs and explore how the mechanisms in the brain are affected by them? IMO, they will then find CFS and PEM are neurological events triggered