Very High Rates of Gynecological Disorders Found in CDC Chronic Fatigue Syndrome Study


Founder of Health Rising and Phoenix Rising
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Amazingly consistent results with every one of 10 gynecological conditions significantly increased in ME/CFS. This is the second CDC study to find this...

Menopause. 2015 Feb 2. [Epub ahead of print] Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women. Boneva RS1, Lin JM, Unger ER.

This study aims to examine whether gynecologic conditions are associated with chronic fatigue syndrome (CFS).

This study includes a subset of 157 women from a population-based case-control study in Georgia, United States, conducted in 2004-2009. Gynecologic history was collected using a self-administered questionnaire. Crude odds ratios (ORs) with 95% CIs and ORs adjusted for body mass index and other covariates, where relevant, were estimated for gynecologic conditions between 84 CFS cases and 73 healthy controls.

Cases and controls were of similar age. Women with CFS reported significantly more gynecologic conditions and surgical operations than controls: menopause status (61.9% vs 37.0%; OR, 2.37; 95% CI, 1.21-4.66), earlier mean age at menopause onset (37.6 vs 48.6 y; adjusted OR, 1.22; 95% CI, 1.09-1.36), excessive menstrual bleeding (73.8% vs 42.5%; adjusted OR, 3.33; 95% CI, 1.66-6.70), bleeding between periods (48.8% vs 23.3%; adjusted OR, 3.31; 95% CI, 1.60-6.86), endometriosis (29.8% vs 12.3%; adjusted OR, 3.67; 95% CI, 1.53-8.84), use of noncontraceptive hormonal preparations (57.1% vs 26.0%; adjusted OR, 2.95; 95% CI, 1.36-6.38), nonmenstrual pelvic pain (26.2% vs 2.7%; adjusted OR, 11.98; 95% CI, 2.57-55.81), and gynecologic surgical operation (65.5% vs 31.5%; adjusted OR, 3.33; 95% CI, 1.66-6.67), especially hysterectomy (54.8% vs 19.2%; adjusted OR, 3.23; 95% CI, 1.46-7.17). Hysterectomy and oophorectomy occurred at a significantly younger mean age in the CFS group than in controls and occurred before CFS onset in 71% of women with records of date of surgical operation and date of CFS onset.

Menstrual abnormalities, endometriosis, pelvic pain, hysterectomy, and early/surgical menopause are all associated with CFS. Clinicians should be aware of the association between common gynecologic problems and CFS in women. Further work is warranted to determine whether these conditions contribute to the development and/or perpetuation of CFS in some women.


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I am 52. I became pregnant at 45.This was unplanned. I had a very difficult pregnancy, and was on 1500 mg. FAMVIR pd. Without this I could not function at all. I have had UTIs my whole life, and constant problems with ovarian cysts. I had one removed after my first pregnancy, which had fully developed molars and human hair in it, but this was before I became seriously ill. The others were fluid. I bleed between periods, and spend at least 3 days in bed during cycles, due to vomiting, severe pelvic pain, and migraine. I now have at least a 7 day period, and it drains me completely. The bleeding is excessive, and I faint on occasion.

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