The only time I've taken niacin or B-3 by itself was during Dr. Rea's sauna program. Niacin was taken before getting in the sauna in order to help flush one's system of toxins. If you've never taken it small amounts of can turn your face and body beet-red and make you feel as you're about to explode... It's quite an experience. @waiting recommended that I try it by itself. She said it was one the few things that really helped her during her really dark years. I gave it a try....I turned beet red; it felt like my body was going to explode with heat and then as that effect diminished I felt very calm (really unusual for me) and really clear. My cognitive abilities definitely went up for awhile and my chemical sensitivities disappeared.....It was wonderful. I've taken it several times since then. Once when I was stuck inside my van when it was raining. Something in the van was making me nauseous. I felt horrible but then the niacin worked again; after the initial "explosion" my system calmed down and my chemical sensitivities completely disappeared! This has happened several times. I don't take it too often because I'm afraid of developing tolerance - something I tend to do with things that help me - but invariably its as if the cobwebs disappear, I can see and think more clearly, my chemical sensitivities (if present diminish) and my energy picks up a bit. Niacin In sauna Niacin is believed to I wonder if niacin's effect on me have to do with its ability to dilate blood vessels. That dilation, though, only occurs near the skin Dr. David Williams believes that improves circulation in the legs. Nobody seems to connect it with producing calmness and helping with chemical sensitivity except in connection with a sauna program. http://thedetoxspecialist.com/blog/cleansing/flush-out-chemicals-with-a-niacin-detox/ Wikipedia WebMD WebMD says a lot of good things about niacin but does have some warnings about it: Some sites warn against taking 750 mg or more a day.