https://www.sciencedaily.com/releases/2016/03/160303084355.htm
"Our observation also explains why the replacement of a single nucleotide for another in the inactive fragment of DNA can cause a person to become susceptible to a disease," says Prof. Wilczyński and explains: "If a change occurs, for example, within the CTCF protein binding site, it may not be able to serve as a velcro. As a result, the proper chromatin loop cannot form, leading to the changes in the geometric conditions in which RNA polymerase II transcribes genes."
"Our observation also explains why the replacement of a single nucleotide for another in the inactive fragment of DNA can cause a person to become susceptible to a disease," says Prof. Wilczyński and explains: "If a change occurs, for example, within the CTCF protein binding site, it may not be able to serve as a velcro. As a result, the proper chromatin loop cannot form, leading to the changes in the geometric conditions in which RNA polymerase II transcribes genes."
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