23andme TRPM3 SNPs for CFS - Griffiths Research

Discussion in 'Mast Cell and Histamine' started by Remy, May 3, 2017.

  1. Remy

    Remy Administrator

    I'm confused! Do you think you could rephrase your question? Like you say, it appears you have one wild type, one heterozygous mutation, and three homozygous mutations.
  2. Lissa

    Lissa Well-Known Member

    I guess I'm confused with what is important here... the fact that I have the genes (no matter if there are mutations or not), or if it is the particular mutations that matter.

    When I first read the original chart, I interpreted it to mean that ME/CFS was indicated by matching the genes AND the particular mutations/wild types exactly as listed.

    Using that methodology --- only 1 of mine matches the chart exactly. The rest are "there", but not a match by hetero/homo/wild.

    Which then leads to genetics 101--- which I struggled with in college, long long ago! Are these "ME/CFS" genes found in everyone--- like the coding for eye color? Or are these genes being singled out as something unusual that is unique to ME/CFS? So someone healthy totally doesn't have these at all?

    Hope I'm making sense. I can barely follow my own wonderings! Ha!
  3. Issie

    Issie Well-Known Member

    Here is a write up from @Cort on this. I'm also pasting an observation of mine I posted in answer to if snps can be found on 23&me - I listed this thread. Thanks @Remy for the info on that!


    Yes, 23&me has some snps to identify. Some of us have them.

    I reread your blog @Cort, and noticed they first had to deplete the calcium and then work on upping the TRPM4 receptors. That would fit with what works for me. GastroCrom and Tramadol are both mild calcium channel blockers (this keeps calcium from going into the cells properly and causes a vasodilation affect) – I use those at night. Then in the a.m. use Pregnenolone which can up this action of TRPM3. This seems like this is a fine balancing act and may be something to do with receptors or autoimmune dysfunction. If we could tweak and create an epigenetic response to over ride these mutations (which is probably what I’m doing) things get better. In addition to working on MTHFR mutations and upping acetylcholine, I’m much improved. Also thinning my blood with herbs (due to APS) is helping alot
  4. Remy

    Remy Administrator

    I think everyone has these TRPM3 genes...that's why they are included on the 23andme chip. But the mutations, or SNPs, seem to be unique to ME/CFS.
    Lissa likes this.
  5. Remy

    Remy Administrator

    The way I read your results, you have three homozygous mutations, one heterozygous, and one "normal" as indicated by their red, yellow and green colors. Hope that helps!
    Lissa likes this.
  6. Farmgirl

    Farmgirl Well-Known Member

    @Remy Wanted to "like" those last two posts on SNPS above, but there is nothing to "like" about them.

    Sorry about your SNPS.FG
  7. Farmgirl

    Farmgirl Well-Known Member

    @Issie. Can you please explain what APS is? I have had clotting issues for 25 years but they have gotten a lot worse...so if I do not stay on aspirin and vitamin E, i Will get clots in my legs that are superficial, never deep, so far. Thanks! FG