Mandalorian
Member
Since all these theorys flying about what cause CFS , i thought i throw one more on the long line.
I would call the condition CFS as the collapse of extracellular matrix(ECM ) The events that cause the collapse of ECM, is because our environment has changed so much from the time ancestors lived, and our body are just not made to this new deal where our bodys are bombarded more and more toxins and same time food nutrional values have drop down also.
Since the ECM is whole body system, and interacts between cells , transport all kinds of things and messages etc it have so wide range of effects also when it start go down/clogged. I think the variations that can result from just this one malfunctionin body component are just too many, from one individuals to another as people are also different and can produce different biological markers .What i mean , is that while there are known similarities observed with bio markers between CFS patients, the root cause has been not really claimed to been find, even with all registered bio markers out there . I am not claiming ECM collapse as the ultimate cause, yet it is the furthest point i have gone in this , and i been wondering this for years. Yet by looking all the different variations, bio markers that is finded every year is like needle in a haystack, at least i am tired to even read them much as the storys are missing on what reason body makes them.
With the ECM collapse, i really doubt that by looking just a virus as the cause for CFS is the answer . What set`s the whole immune system on and off against outsider pathogens, or set the immune system to down or up, to autoimmunity or lowered state is to me closer the root than a virus ,was it EBV or other. A common virus like EBV probably need weak host to start cause permanent chronic disease. With ECM collapse , we are not anymore in the normal immune system gategory, things have got compromised , and so it`s more like a waiting game when some bug start causing more issues ,CFS or other.
It`s bit hard to go very technical about the extracellular matrix here, what all it do and what impact it has to body when it is clogged/collapsed, i link some to getting at least some wiew hopefully, with search engines there is more info also.
I think the German biological medicine is on correct path with understanding the nature how our body work . The whole issue is " systemic " big time, and can then also create very wide range of different diseases, bio markers , symptoms . The ECM itself consist different materials, also fluids. If i have understand right from quite technical texts, oxygen is one of the things that should be transported also in ECM . And as we know, PEM is common feature in CFS , so does that have to do maybe with the lack of oxygen if ECM is clogged and cant keep up with the demand of oxygen , at least a maybe i think ,until knowing better.
I have CFS, thought i feel it is getting better , i will continue a clean way, do detox and wash my teeth .
Added 2 links about extracellular fluid and oxygen transport:
biologydictionary.net
en.wikipedia.org
And a video about Interstitial Fluid , which is part of the extracellular matrix :
So IF ? someone would have some serious issues with extracellular matrix, Interstitial Fluid , the mechanism that carry nutrients to cells and visa versa toxic waste to blood out from extracellular matrix would be compromised .
I forget to add one importante article by dr.Sarah Carnes, ND . :
sarahcarnesnd.com
"
What aluminum does in the body
There are too many negative health effects of aluminum to go into detail about them all. I'm going to go into detail about the most significant and common effect that I see clinically: the collapse of the extracellular matrix. To clarify that this is by no means the only problem, here's a short and sort of technical list of some of the other known effects:
This is a key mechanism of aluminum toxicity and even if you've never heard the term "extracellular matrix" (maybe especially if you've never hear the term), it's worth understanding why this is a problem. This is a long explanation, but it's worth it, if you want to understand for yourself, clearly and simply, why this is a real problem. There are a number of underlying concepts that, when understood and tied together at the end, show a simple and clear picture of how and why aluminum is so toxic.
A healthy ECM is constantly restructuring itself to accommodate the changing needs of cells based on circadian rhythms, larger hormonal cycles, activities different parts of the body are doing: digesting, running, weight lifting, etc.), how long ago food was eaten, etc. Cells are dependent on the ECM functioning well, so anything that disrupts it in a significant way becomes central to health. You could think of the ECM as a wet dish sponge, with the cells of body living in the holes. If that sponge was dried out or damaged, it makes sense that cells wouldn't be as easily able to get nourishment or other things that they need.
The ECM is a combination of 1) structural proteins (collagen and hyaluronic acid are some of the better known ones) that act and look like a cross between architectural scaffolding or bottle brushes and radio antennas, and 2) the fluid surrounding them (water with varied electrolytes, proteins, and other tiny molecules, which have a certain electric charge) which keeps the scaffolding/antennas upright and in a working position.
The structural proteins (generically called glycoproteins) are like seaweed. When seaweed is underwater, it's upright, moving, fanning, colorful, etc., but at low tide, when it's above water, it's collapsed into a goo ball on the rocks, and if you didn't know better, you would assume it was dead. In a sense it is, because many of the processes required for seaweed to survive can only happen when its structure is expanded. The inside of a human body is always "underwater". There's never a time, like low tide for seaweed, that the matrix should be collapsed, yet it can happen.
The presence of the fluid, along with its proper mildly positive electrical charge, is what keeps the scaffolding, which has a mild negative charge, upright and fanning. As an example to make the point: dehydration and electrolyte imbalances can both cause collapse of the ECM, more severely, the more severe the dehydration or imbalance is.
This can be seen visually by the pinch test, a quick means to determine whether someone has dehydration (though the test doesn't work for anything less than severe, life-threatening dehydration): pinch the patient's skin, release it, and it should bounce back to its normal position immediately. If it is delayed or doesn't bounce back, that's the ECM equivalent to a pile of seaweed salad on a plate that you can mold into a certain shape and all it will do is sit there, whereas if you stuck your hand in an aquarium and balled up living seaweed, once you let go of it, it would immediately resume its flexible, fanned-out shape.
Aluminum ions also collapse the structure. Some of the aluminum that we are concerned about has a 3+ charge. "3+" is chemistry terminology for how electrically strong or weak a charged particle is (neutral is 0), and therefore how strongly it will attract or repel other charged particles.
Size of the particle also matters, because whatever charge(s) a molecule has, simplified, is spread over the surface of that molecule, so smaller particles, since the charge is concentrated in a smaller area, will have a stronger attractive/repulsive force. Al3+ (chemistry shorthand for aluminum with a 3+ charge) is a particularly small ion (its atomic number/the number of protons it has, which indicates its size, is 13; by comparison, lead is 82, mercury is 80), and 3+ is a strong charge for an ion.
When these Al3+ particles are thrown into the ECM, they completely override the milder positive charge of the diffuse ambient fluid, draw the negatively charged structural proteins to them, and hang on tightly, collapsing them like seaweed drying on the shore, and keeping them in that collapsed state until the aluminum is removed, if it ever is.
What happens to the cells when the ECM has collapsed?
The cells, surrounded by a collapsed network of glycoprotein goo instead of the adaptable, flexible, moving matrix, are physically and electrically gummed up and all tasks become less efficient and less accurate. Further, since the ECM also controls the routes of nutrients in and waste products out, fundamental needs for survival become limited.
As an example: imagine that you cannot, for any reason, leave your house. Even though you can't leave, there's someone who delivers food to your house regularly and a garbage truck and the plumbing take away your waste. Now imagine, Sleeping Beauty style, that huge thorn bushes have grown up all around your house. The food deliverer sometimes can't get in at all, and when he can make it through the thorns, he might have dropped half of the food on the way. The garbage truck driver has basically given up getting his truck anywhere close and trash is piling up, and the roots have broken through the plumbing.
At the same time that trash and poop is building up in your house, you're starting to starve. All kinds of problems are going to arise, eventually leading to death. If this "person in the house" is a liver cell, the body will not detox as well. If it's a neuron, there is going to be some abnormal neurological activity (too much: seizures, twitches, pain, excessive sensitivities to stimuli, etc.; or not enough: numbness, paralysis, brain fog, etc.). If it's a muscle cell, it will be weak and fatigue easily. Whatever that cell is supposed to do, it will not do it effectively.
Organs or cells that were already weak due to some past trauma, infection, psychological issue, etc. are going to struggle more and fail faster than those that had a full reserve of health to begin with, which in part explains why individuals will have different systems affected and different types of symptoms from the same pathology of the ECM being clogged due to aluminum toxicity.
The ECM transmits electricity and other energies as well. There is some evidence that the energy of the meridians, as recognized in Chinese and other forms of medicine, is transmitted through the ECM. While there are other reasons as well, I have observed that patients with collapsed ECM's tend to not respond to acupuncture, homeopathy, and other forms of medicine that manipulate the bodily energy at that level.
A collapsed ECM makes someone poor at grounding, no matter how much they stand barefoot outside, because the electrical signal, wherever it enters the body, faces a lot of electrical resistance, and this can cause some of the localized symptoms of electrohypersensitivity, like headaches or other symptoms in specific areas of the body, often including those parts that are closest to WiFi routers, cell phones, baby monitors, etc. Further, aluminum coating the cells makes a person an antenna, like old school television rabbit ears, boosted with fans of aluminum foil. In my clinical experience, in some cases, the main cause of electrohypersensitivity is an ECM having lost its conductance.
Perspective on the problem
After all of these words about how bad aluminum toxicity is, I need to clarify that aluminum is not some inherently evil substance, worthy of demonization. It's a natural component of the earth, presumably a key component (because everything in the natural world is a product of something else and contributes to the production or creation of something else, ad infinitum), even if we don't understand exactly why. Aluminum oxide, crystallized, is corundum, the class of minerals that includes rubies, sapphires, and rarer gems. Biological life did not evolve with the massive amounts and unnatural types of aluminum and other metals in our environment. Our systems are not adept at dealing with it, because until a few generations ago, they never had to. It's a new insult and, to anthropomorphize a bit, it's not the aluminum's fault that humans dug it out of the earth and transformed it into a poison.
sarahcarnesnd.com
I would call the condition CFS as the collapse of extracellular matrix(ECM ) The events that cause the collapse of ECM, is because our environment has changed so much from the time ancestors lived, and our body are just not made to this new deal where our bodys are bombarded more and more toxins and same time food nutrional values have drop down also.
Since the ECM is whole body system, and interacts between cells , transport all kinds of things and messages etc it have so wide range of effects also when it start go down/clogged. I think the variations that can result from just this one malfunctionin body component are just too many, from one individuals to another as people are also different and can produce different biological markers .What i mean , is that while there are known similarities observed with bio markers between CFS patients, the root cause has been not really claimed to been find, even with all registered bio markers out there . I am not claiming ECM collapse as the ultimate cause, yet it is the furthest point i have gone in this , and i been wondering this for years. Yet by looking all the different variations, bio markers that is finded every year is like needle in a haystack, at least i am tired to even read them much as the storys are missing on what reason body makes them.
With the ECM collapse, i really doubt that by looking just a virus as the cause for CFS is the answer . What set`s the whole immune system on and off against outsider pathogens, or set the immune system to down or up, to autoimmunity or lowered state is to me closer the root than a virus ,was it EBV or other. A common virus like EBV probably need weak host to start cause permanent chronic disease. With ECM collapse , we are not anymore in the normal immune system gategory, things have got compromised , and so it`s more like a waiting game when some bug start causing more issues ,CFS or other.
It`s bit hard to go very technical about the extracellular matrix here, what all it do and what impact it has to body when it is clogged/collapsed, i link some to getting at least some wiew hopefully, with search engines there is more info also.
German Biological Medicine | Circle Of Health Clinic
An Elegant and Effective Means of Health RestorationThis strategy facilitates:"Drainage" and detoxification of specific tissues, allowing them to return to a
circleofhealthclinic.com
http://circleofhealthclinic.com/wp-content/uploads/2015/12/Drainage-and-the-Extracellular-Matrix.pdf
I think the German biological medicine is on correct path with understanding the nature how our body work . The whole issue is " systemic " big time, and can then also create very wide range of different diseases, bio markers , symptoms . The ECM itself consist different materials, also fluids. If i have understand right from quite technical texts, oxygen is one of the things that should be transported also in ECM . And as we know, PEM is common feature in CFS , so does that have to do maybe with the lack of oxygen if ECM is clogged and cant keep up with the demand of oxygen , at least a maybe i think ,until knowing better.
I have CFS, thought i feel it is getting better , i will continue a clean way, do detox and wash my teeth .
Added 2 links about extracellular fluid and oxygen transport:
Extracellular Fluid - Definition and Quiz | Biology Dictionary
Extracellular fluid is the term for the many fluids that exist in an organism outside of cells of the organism, but sealed within the body cavities and vessels.
Extracellular fluid - Wikipedia
And a video about Interstitial Fluid , which is part of the extracellular matrix :
So IF ? someone would have some serious issues with extracellular matrix, Interstitial Fluid , the mechanism that carry nutrients to cells and visa versa toxic waste to blood out from extracellular matrix would be compromised .
I forget to add one importante article by dr.Sarah Carnes, ND . :
Solutions to aluminum toxicity, pt 1 — Dr. Sarah Carnes
Aluminum is one of the most common toxicities today. It's not enough to avoid aluminum containing deodorants, aluminum foil and cookware, etc. Due to environmental contamination, it's in the air, soil, food plants, water, etc. as well as commercial products, under a false presumption of safety.
sarahcarnesnd.com
"
What aluminum does in the body
There are too many negative health effects of aluminum to go into detail about them all. I'm going to go into detail about the most significant and common effect that I see clinically: the collapse of the extracellular matrix. To clarify that this is by no means the only problem, here's a short and sort of technical list of some of the other known effects:
Collapse of the extracellular matrix (ECM)
This is a key mechanism of aluminum toxicity and even if you've never heard the term "extracellular matrix" (maybe especially if you've never hear the term), it's worth understanding why this is a problem. This is a long explanation, but it's worth it, if you want to understand for yourself, clearly and simply, why this is a real problem. There are a number of underlying concepts that, when understood and tied together at the end, show a simple and clear picture of how and why aluminum is so toxic.
The extracellular matrix surrounds every cell in the body (which is why it has the name that it does: "extra": outside; "cellular": of the cell; the matrix outside of the cell—all cells!), controlling their interaction with other cells and parts of the body near and far, controlling the entry and exit of nutrients and waste products, whether or not nearby circulation is open or choked off, whether accurate and appropriate signals from the nervous system can reach the cells, etc.
A healthy ECM is constantly restructuring itself to accommodate the changing needs of cells based on circadian rhythms, larger hormonal cycles, activities different parts of the body are doing: digesting, running, weight lifting, etc.), how long ago food was eaten, etc. Cells are dependent on the ECM functioning well, so anything that disrupts it in a significant way becomes central to health. You could think of the ECM as a wet dish sponge, with the cells of body living in the holes. If that sponge was dried out or damaged, it makes sense that cells wouldn't be as easily able to get nourishment or other things that they need.
The ECM is a combination of 1) structural proteins (collagen and hyaluronic acid are some of the better known ones) that act and look like a cross between architectural scaffolding or bottle brushes and radio antennas, and 2) the fluid surrounding them (water with varied electrolytes, proteins, and other tiny molecules, which have a certain electric charge) which keeps the scaffolding/antennas upright and in a working position.
The structural proteins (generically called glycoproteins) are like seaweed. When seaweed is underwater, it's upright, moving, fanning, colorful, etc., but at low tide, when it's above water, it's collapsed into a goo ball on the rocks, and if you didn't know better, you would assume it was dead. In a sense it is, because many of the processes required for seaweed to survive can only happen when its structure is expanded. The inside of a human body is always "underwater". There's never a time, like low tide for seaweed, that the matrix should be collapsed, yet it can happen.
The presence of the fluid, along with its proper mildly positive electrical charge, is what keeps the scaffolding, which has a mild negative charge, upright and fanning. As an example to make the point: dehydration and electrolyte imbalances can both cause collapse of the ECM, more severely, the more severe the dehydration or imbalance is.
This can be seen visually by the pinch test, a quick means to determine whether someone has dehydration (though the test doesn't work for anything less than severe, life-threatening dehydration): pinch the patient's skin, release it, and it should bounce back to its normal position immediately. If it is delayed or doesn't bounce back, that's the ECM equivalent to a pile of seaweed salad on a plate that you can mold into a certain shape and all it will do is sit there, whereas if you stuck your hand in an aquarium and balled up living seaweed, once you let go of it, it would immediately resume its flexible, fanned-out shape.
Aluminum ions also collapse the structure. Some of the aluminum that we are concerned about has a 3+ charge. "3+" is chemistry terminology for how electrically strong or weak a charged particle is (neutral is 0), and therefore how strongly it will attract or repel other charged particles.
Size of the particle also matters, because whatever charge(s) a molecule has, simplified, is spread over the surface of that molecule, so smaller particles, since the charge is concentrated in a smaller area, will have a stronger attractive/repulsive force. Al3+ (chemistry shorthand for aluminum with a 3+ charge) is a particularly small ion (its atomic number/the number of protons it has, which indicates its size, is 13; by comparison, lead is 82, mercury is 80), and 3+ is a strong charge for an ion.
When these Al3+ particles are thrown into the ECM, they completely override the milder positive charge of the diffuse ambient fluid, draw the negatively charged structural proteins to them, and hang on tightly, collapsing them like seaweed drying on the shore, and keeping them in that collapsed state until the aluminum is removed, if it ever is.
What happens to the cells when the ECM has collapsed?
The cells, surrounded by a collapsed network of glycoprotein goo instead of the adaptable, flexible, moving matrix, are physically and electrically gummed up and all tasks become less efficient and less accurate. Further, since the ECM also controls the routes of nutrients in and waste products out, fundamental needs for survival become limited.
As an example: imagine that you cannot, for any reason, leave your house. Even though you can't leave, there's someone who delivers food to your house regularly and a garbage truck and the plumbing take away your waste. Now imagine, Sleeping Beauty style, that huge thorn bushes have grown up all around your house. The food deliverer sometimes can't get in at all, and when he can make it through the thorns, he might have dropped half of the food on the way. The garbage truck driver has basically given up getting his truck anywhere close and trash is piling up, and the roots have broken through the plumbing.
At the same time that trash and poop is building up in your house, you're starting to starve. All kinds of problems are going to arise, eventually leading to death. If this "person in the house" is a liver cell, the body will not detox as well. If it's a neuron, there is going to be some abnormal neurological activity (too much: seizures, twitches, pain, excessive sensitivities to stimuli, etc.; or not enough: numbness, paralysis, brain fog, etc.). If it's a muscle cell, it will be weak and fatigue easily. Whatever that cell is supposed to do, it will not do it effectively.
Organs or cells that were already weak due to some past trauma, infection, psychological issue, etc. are going to struggle more and fail faster than those that had a full reserve of health to begin with, which in part explains why individuals will have different systems affected and different types of symptoms from the same pathology of the ECM being clogged due to aluminum toxicity.
The ECM transmits electricity and other energies as well. There is some evidence that the energy of the meridians, as recognized in Chinese and other forms of medicine, is transmitted through the ECM. While there are other reasons as well, I have observed that patients with collapsed ECM's tend to not respond to acupuncture, homeopathy, and other forms of medicine that manipulate the bodily energy at that level.
A collapsed ECM makes someone poor at grounding, no matter how much they stand barefoot outside, because the electrical signal, wherever it enters the body, faces a lot of electrical resistance, and this can cause some of the localized symptoms of electrohypersensitivity, like headaches or other symptoms in specific areas of the body, often including those parts that are closest to WiFi routers, cell phones, baby monitors, etc. Further, aluminum coating the cells makes a person an antenna, like old school television rabbit ears, boosted with fans of aluminum foil. In my clinical experience, in some cases, the main cause of electrohypersensitivity is an ECM having lost its conductance.
Perspective on the problem
After all of these words about how bad aluminum toxicity is, I need to clarify that aluminum is not some inherently evil substance, worthy of demonization. It's a natural component of the earth, presumably a key component (because everything in the natural world is a product of something else and contributes to the production or creation of something else, ad infinitum), even if we don't understand exactly why. Aluminum oxide, crystallized, is corundum, the class of minerals that includes rubies, sapphires, and rarer gems. Biological life did not evolve with the massive amounts and unnatural types of aluminum and other metals in our environment. Our systems are not adept at dealing with it, because until a few generations ago, they never had to. It's a new insult and, to anthropomorphize a bit, it's not the aluminum's fault that humans dug it out of the earth and transformed it into a poison.
Solutions to aluminum toxicity, pt 1 — Dr. Sarah Carnes
Aluminum is one of the most common toxicities today. It's not enough to avoid aluminum containing deodorants, aluminum foil and cookware, etc. Due to environmental contamination, it's in the air, soil, food plants, water, etc. as well as commercial products, under a false presumption of safety.
sarahcarnesnd.com
Last edited:
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