https://pubmed.ncbi.nlm.nih.gov/20523772/ When I went bald, during my late teens, I had no idea that the primary cause of my condition was coeliac disease. That took me decades to learn. I also had no idea that dandruff is a sign of skin conditions resulting from either bacterial (staphylococcus) or fungal (malassezia) infections. Funny thing about all of these is that they induce, among other things, zinc deficiency in the skin. Zinc is required not only for preventing sebum from blocking pores of the skin (comedogenic) but also for a wide range of factors affecting both skin health and hair growth. Stem cells, throughout our bodies, change into cells which are required at the time and may revert to being stem cells if the body signals that it requires different cells. Not only does that signaling become disrupted when zinc deficiency occurs but the normal process, stabilising the workhorse cells they have become and preventing them from reverting, lacks the essential zinc needed to maintain it. https://pubmed.ncbi.nlm.nih.gov/35172118/ Conditions such as atopic dermatitis occur in the skin and even the bone of the skull can lose integrity, due to the same stem cell differentiation which occurs in the skin. The normal pattern of alopecia develops because of the galea apotoneurotica, a fibrous mat of collagen which connects the muscles on either side of the scalp. This mat contains numerous fibroblasts, which all require lots of zinc to both maintain their own stem cell stability and to produce all of the required collagen to maintain the apotoneurosis. The scalp on top of the head is like a zinc sponge, requiring constant feeding. So if you add conditions like coeliac disease, inducing nutrient deficiencies, and/or disruption of the top layer of the skin (stratum corneum) allowing infections to enter the skin then that zinc sponge suddenly becomes an open drain. The hair bulges, containing stem cells which produce the hair, rise to the surface of the skin and differentiate into skin keratinocytes and the skin thins. Hair canals need to be at least 4mm deep inside the skin in order to be able to produce mature hair. Ironically, dietary zinc levels don't necessarily equate to tissue zinc levels. Some people have SLC30 or SLC39 gene mutations which reduce the levels of proteins which transport zinc, and other minerals, around the body. Once a zinc deficiency occurs you become even more vulnerable to allergic reactions as zinc helps to prevent Th2 allergic response from switching into Th17 response. https://www.researchgate.net/public...the_Dermis_Particularly_around_Hair_Follicles https://pubmed.ncbi.nlm.nih.gov/20215335/ You always hear people blaming dihydrotestosterone for hair loss but it is the Th2 and Th17 responses which are actually responsible. Interleukin signaling, involved in Th2 and Th17 responses, tells stem cells in the hair bulges to enter resting stage of hair growth. https://pubmed.ncbi.nlm.nih.gov/34281739/ Dihydrotestosterone actually tries to reduce that signaling. https://pubmed.ncbi.nlm.nih.gov/1830499/ As I have read about cases of excessive dietary zinc inducing alopecia I am cautious regarding supplementing the diet. Find a way to reduce the underlying factors inducing zinc deficiency in the scalp and the problem will hopefully be eliminated.