Actually, I have moved on slightly after trying to help someone with schizophrenia. My focus is still on amyloids but I have been looking at the role of p53 amyloid in causing apoptosis (cell death) of diseased cells. Gene variants affecting production of this amyloid cause issues with repair of damaged tissues around the body causing a range of different diseases. I began looking at it for urinary protein loss after reading this article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043292/ If it wasn't for p53 people who undergo chemotherapy wouldn't lose their hair. https://pubmed.ncbi.nlm.nih.gov/11016618/ That leads me to suspect a role in other types of hair loss, particularly now I know about the coating of the pilosebaceous glands with amyloid.Another success story, has this person recovered fully? Who knows
Ken, I now believe that you are correct about the microbiome being part of the base cause of alopecia but it's a little more complex. The basic group of bacteria, containing many different types, which I backtracked all of my lifelong health issues to (with the exception of alopecia) are butyrate producing bacteria. Butyrate is involved in regulation of vasodilation and vasoconstriction, thyroid function, integrity of the intestinal lining, gastrointestinal motility, and a huge range of other factors around the body. A deficiency of butyrate bacteria leads to all different kinds of disease including multiple sclerosis, autism, coeliac disease, Parkinson's, Alzheimer's, dementia, and so on. From what I have read, butyrate bacteria seem to require bifidobacteria since they feed on products which they release. Butyrate bacteria are also highly susceptible to cadmium so are highly reliant on the presence of bacteria such as lactobacillus for protection against cadmium. Unfortunately there doesn't seem to have been any research connecting butyrate bacteria deficiency with alopecia but I am convinced, given my familial health issues and all of the medical research I have looked at, that they are the wellspring from which everything, including the alopecia, flows. Because of their protective effect in the intestines their deficiency leads to poor nutrient uptake. It may be possible to use all of the previously discussed nutritional interventions to protect against hair loss but I am now choosing to alter my strategy to a focus on increasing levels of bifidobacteria and butyrate bacteria.