Could alopecia be as simple as a zinc deficiency?

[Aidan Walsh]

Hopefully that provides you with the answer you need. I won't deny some interest as I have a compressed artery on top of each of my feet and think it's a distant possibility that I might have the same but for now I'm limited to my own efforts to try to fix my condition. I have to admit to hoping that improving my thyroid function will fix many health issues, including vascular problems.

I have still a long way to go but in the meantime, while you wait there is a certain medicine that has been used in 4 people their NC went away entirely & as I mentioned it was the thing you mentioned on thrombosis.

I think the pulmonary type of medicine used I may have already downloaded the paper here from Japan if not I can attach it here if I still have this

 

[Aidan Walsh]

Maybe they would get off their asse

I appreciate the thought but doctors have pretty much gone into lockdown on me to try to prevent any further investigations which would uncover their peers incompetence. A prior GP who attempted to help me with investigations implied that his career had been threatened for helping me fight for investigations. Friends have described them as being determined to bury their mistakes with me. The local hospitals pulled out every excuse in order to avoid completing medical investigations of my autoimmune myositis while still claiming that there is there is nothing significantly wrong with my health. Even with the diagnosis of the chronic thromboembolic pulmonary disease they still argue the same thing despite the fact that it proves that I can't walk more than a few steps at a time without dangerously raising my heart rate.

Maybe, they would get off their Asses, if they did the right or proper testing

 

[Baz493]

Maybe they would get off their asse

Maybe, they would get off their Asses, if they did the right or proper testing

I've said that from the beginning but you sometimes just need one doctor to screw up badly enough and then the cover up begins, denying you medical investigations like they did me. I had to fight to get every last investigation I received and wouldn't have received them if it weren't for a couple of doctors help, one of whom indicated that he had received intimidation from the hospital due to his support for me. As a specialist said, after I gave him a full list of my diagnoses when he told me that the hospital had passed along information to him stating that there was nothing significantly wrong with my health; 'It's suspicious'. That was even before I received the diagnosis of chronic thromboembolic pulmonary disease which I had showed symptoms of for the previous ten years. Trust me that, when doctors go bad, they really go bad.

 

[Aidan Walsh]

I've said that from the beginning but you sometimes just need one doctor to screw up badly enough and then the cover up begins, denying you medical investigations like they did me. I had to fight to get every last investigation I received and wouldn't have received them if it weren't for a couple of doctors help, one of whom indicated that he had received intimidation from the hospital due to his support for me. As a specialist said, after I gave him a full list of my diagnoses when he told me that the hospital had passed along information to him stating that there was nothing significantly wrong with my health; 'It's suspicious'. That was even before I received the diagnosis of chronic thromboembolic pulmonary disease which I had showed symptoms of for the previous ten years. Trust me that, when doctors go bad, they really go bad.

 

[Aidan Walsh]

Let's forget about all the long name CTPD lets go with Thrombo which is involved with Nutcracker Syndrome & Yes there are diagnostic tests for this

 

[Baz493]

Again, I understand that but doctors keep telling me to give up trying to force investigations to happen. I've had that for ten years, since one incompetent doctor at the hospital decided to cover up his own errors in treatment by claiming that I have been faking my condition in order to try to take my former employer to court. Since then most doctors have just accepted that I am going to suddenly get better by magic no matter what I have told them or been diagnosed with. Only a few doctors have willingly helped me to try work out what collapsing from heat stroke did to me. Although I now have a pretty good idea that my liver failed just prior to the collapse it's impossible to get doctors to accept the evidence no matter how much I have obtained.

 

[Aidan Walsh]

YouTube Dr. Osborne Zone 3 parts: Cure for autoimmune diseases discovered, something natural. I have no clue what it is now.

Also, as I mentioned you might be able to get the blood thinner used in this paper of 4 people used in 2021 Japan write down both names of the medicine it mentions one name but try to find the Generic name.

Try to do the NC tests starting with the proper urine proteinuria good-one & blood the urine dipstick test hematuria, any Doctor does these tests...Doppler Ultrasound gradient variant one is Normal hers was a 7 then the Veno one in the paper...

 

[Aidan Walsh]

Again, I understand that but doctors keep telling me to give up trying to force investigations to happen. I've had that for ten years, since one incompetent doctor at the hospital decided to cover up his own errors in treatment by claiming that I have been faking my condition in order to try to take my former employer to court. Since then most doctors have just accepted that I am going to suddenly get better by magic no matter what I have told them or been diagnosed with. Only a few doctors have willingly helped me to try work out what collapsing from heat stroke did to me. Although I now have a pretty good idea that my liver failed just prior to the collapse it's impossible to get doctors to accept the evidence no matter how much I have obtained.

2nd comment, if you have undiagnosed Nutcracker Syndrome file later a damages Lawsuit in Court...

 

[Baz493]

YouTube Dr. Osborne Zone 3 parts: Cure for autoimmune diseases discovered, something natural. I have no clue what it is now.

Also, as I mentioned you might be able to get the blood thinner used in this paper of 4 people used in 2021 Japan write down both names of the medicine it mentions one name but try to find the Generic name.

Try to do the NC tests starting with the proper urine proteinuria good-one & blood the urine dipstick test hematuria, any Doctor does these tests...Doppler Ultrasound gradient variant one is Normal hers was a 7 then the Veno one in the paper...

I spent ten years trying to get a lawsuit going against the doctors so that I could take the company I had worked for to court but Australian law is backwards. Doctors here almost always back each others opinions so, when a doctor claims that you are faking your condition and the hospital they work at spends years blocking you from receiving any medical investigations as your health collapses, it becomes extremely hard to find a doctor who will be willing to challenge them. Although I was eventually able to find a couple of doctors who helped me to prove that I have serious medical conditions I have been unable to find a medical specialist willing to challenge their peers in court and lawyers say that medical lawsuits here are impossible without that backing. We aren't like the US where it's relatively easy to get a lawsuit going. If my cognitive function hadn't been impacted by the events which caused my condition I might have been inclined to try representing myself in court just to get my case heard in court but I just don't have that level of function now.

I took a look at the video. While I agree with what he says I felt that his perspectives were fairly simplistic in many ways. I have tried to restrict myself to posting about alopecia and chronic fatigue on this forum but have discussed a wide range of diseases with people on other forums and try to look at things like the molecular mimicry which he mentioned but the subject is so much deeper than he briefly covered. As for autoimmune disease itself it was found, years ago, that it is possible to do a reset on our bodies with sodium bicarbonate. It primarily works by resetting the immune system through our spleens. It's not a cure for autoimmune disease but I view it as a way to give our conditions an extra push after we have done sufficient dietary work to reverse our conditions. Since the bicarbonate can help to trigger normal breathing response I am holding off on using it to try to help my respiratory condition until I have my health restored to a point where it won't be too much of a risk to try it. Sodium bicarbonate can cause as many health conditions as it can help with so it's essential not to use it without respect and great caution.

 

[Aidan Walsh]

There is a Guy on here who swears by baking soda he used with certain antibiotics for Lactate C Acidosis he is well now. He believes it was the baking soda combo that did the trick. This is not the L Lactate Acidosis it is different but can be tested for by trying to find a specialist involved.

Do not forget to rule out if you can the Latent TB from Birth that way you know you are clear. The NIH Study on the Woman was funded by the ME Association whose family had some genetic illness she was the only one fatigues all others were Negative to the Protein.

If you look on Me Association its there...I will let you know if I find out anything else on here or my tests

 

[Baz493]

This evening I found what I believe is the biggest clue so far. This article, although discussing bone related osteoclasts, describes how they are able to activate TGF-beta signaling without retinol to some degree but require retinol for full activation. https://pubmed.ncbi.nlm.nih.gov/9003000/ Given everything I have read to date I believe that this is what occurs with active cells of various kinds and that this is the reason for defective TGF-beta signaling in alopecia and many other health conditions. The problem, in many cases, is reduced retinol binding protein 4 levels so resulting in reduced transport of retinol to tissues and the scalp. This seems to occur in cases of zinc deficiency. https://pubmed.ncbi.nlm.nih.gov/1036344/

 

[Aidan Walsh]

This evening I found what I believe is the biggest clue so far. This article, although discussing bone related osteoclasts, describes how they are able to activate TGF-beta signaling without retinol to some degree but require retinol for full activation. https://pubmed.ncbi.nlm.nih.gov/9003000/ Given everything I have read to date I believe that this is what occurs with active cells of various kinds and that this is the reason for defective TGF-beta signaling in alopecia and many other health conditions. The problem, in many cases, is reduced retinol binding protein 4 levels so resulting in reduced transport of retinol to tissues and the scalp. This seems to occur in cases of zinc deficiency. https://pubmed.ncbi.nlm.nih.gov/1036344/

So, if this is what it is what can be done? I watch Mystery Diagnosis one learns a lot & other Mystery types of diagnoses, one Woman said she had Mono then Lyme then said it was Arthritis, turns out she had a Massive Tumor removed it

was Cervical Cancer, another told her she had Mono then another thing then thought it was in her Head, her Mom refused they took some of these meds

with no help then brought to a long-term sleep center turns out she had KLS Kleine Levin Syndrome some do recover in time, she was given Ritalin there is no Cure presently.
Also, some need Vasopressin if they have Pituitary Tumors or if they were injured on the Gland in accidents or sports or fights 24-hour no water allowed tests in the hospital

 

[Baz493]

Quite simply; many diseases have the same sets of symptoms so, without tests necessary to confirm a specific condition, it's impossible to be absolutely certain of a specific diagnosis. Often, even the same tests can apply to multiple health conditions so if they miss doing a crucial test then it can mean the difference between a correct diagnosis and a flawed one. It's also very common for the same set of biological reactions to result in very different diseases because of genetic factors. Since there isn't any way for me to be certain regarding the reasons why everyone loses their hair, given all of the possible genetic factors which can be involved, I have been trying to stick to finding the key determining factors which routinely occur in the condition as observed in medical research. Those seem to be the combination of allergy and cadmium exposure, resulting uptick in retinoic acid production (and reduction in retinol), zinc deficiency induced reduction in retinol binding protein 4 levels in the blood resulting in low retinol levels in skin, resulting low TGF-beta signaling with consequent dermatitis and hair loss. Other factors, such as genetically low levels of zinc transporter proteins, can result in these things but it's impossible to factor in every possible combination of genetic causal factors. I have been looking at research which connect together these same factors in hair loss risk, cancer risk, autism risk, schizophrenia risk, liver disease risk, diabetes risk, PCOS risk, MCAS risk, and so on and on.

 

[Aidan Walsh]

Quite simply; many diseases have the same sets of symptoms so, without tests necessary to confirm a specific condition, it's impossible to be absolutely certain of a specific diagnosis. Often, even the same tests can apply to multiple health conditions so if they miss doing a crucial test then it can mean the difference between a correct diagnosis and a flawed one. It's also very common for the same set of biological reactions to result in very different diseases because of genetic factors. Since there isn't any way for me to be certain regarding the reasons why everyone loses their hair, given all of the possible genetic factors which can be involved, I have been trying to stick to finding the key determining factors which routinely occur in the condition as observed in medical research. Those seem to be the combination of allergy and cadmium exposure, resulting uptick in retinoic acid production (and reduction in retinol), zinc deficiency induced reduction in retinol binding protein 4 levels in the blood resulting in low retinol levels in skin, resulting low TGF-beta signaling with consequent dermatitis and hair loss. Other factors, such as genetically low levels of zinc transporter proteins, can result in these things but it's impossible to factor in every possible combination of genetic causal factors. I have been looking at research which connect together these same factors in hair loss risk, cancer risk, autism risk, schizophrenia risk, liver disease risk, diabetes risk, PCOS risk, MCAS risk, and so on and on.

Can you not ask your Doc to do a simple test on Color Doppler of left renal vein gradiants hers was a 7 normal is a1,

Some on here have non-Hodgkins Lymphoma which can cause hair loss

 

[Aidan Walsh]

She also said approach them with urine tests for ACR Albumin Creatinine Ratio.
I know they do 8 hours night supine then test 18 hours awake up

My Creatinine is usually lower than normals in blood & also ask for blood urine. You can buy urine sticks to test it as well, if you can get protein urine sticks it may get them to act.
What can you do if you have what you found?

 

[Baz493]

Can you not ask your Doc to do a simple test on Color Doppler of left renal vein gradiants hers was a 7 normal is a1,

Some on here have non-Hodgkins Lymphoma which can cause hair loss

I don't think that Australia is alone in having lazy doctors since I've read too many stories about the difficulties faced by patients in many countries. Over the last few years I have pushed the limits of testing in order to get a wide range of diagnoses. You wouldn't believe me how much online research I had to do to convince doctors to refer me for those tests since it was almost impossible finding doctors willing to even refer me for a single test and I needed to present really good arguments for the need for the tests. I don't know whether you have heard but both health insurance companies and public health systems place limits on the number of tests which doctors can refer patients for and doctors can face a great deal of scrutiny if they are seen to refer their patients for more tests than their peers deem reasonable. The simple fact is that, even though many of the tests I have been referred for have proven that I have serious health issues doctors have made so many mistakes in my case that there are many people working to deny me further medical investigations which will prove those mistakes. My current GP told me that I needed to give up trying to fight the system and to stop asking for tests. Friends long ago told me that the local health system wants me dead in order to 'bury their mistakes'.

 

[Baz493]

Since my gall bladder was removed, a few years ago, I haven't had any raised creatinine levels so the only urine loss I experience is blood proteins. As for what I can do about things I have found in research I have already reduced vitamin A intake, which was really high before (with lots of dairy), in order to reduce retinoic acid production and have increased my zinc and iron intake to try to force out cadmium while also increasing levels of retinol binding protein in my blood. I removed my main allergen, gluten, from my diet over a decade ago so now it's about trying to support my kidneys ability to repair itself. I am also looking at a variety of different options for detoxing my body of cadmium, including things like zeolite and milk thistle.

 

[Ken Lassesen]

To me, it's a microbiome imbalance. From the citizen science project on the microbiome, some 85 bacteria appears to be involved see the list here. High Blautia has the strongest association

 

[Baz493]

Since my last post I have moved on from the effects of cadmium onto how it affects amyloid deposition and that fits in with the microbiome. I was surprised to find out that the protein which carries retinol in our bloodstream RBP4 is also called amyloid A. That's why high levels of RBP4 can lead to excessive amyloid deposition in tissues all around the body, though there are many other amyloids which our bodies use in a variety of processes. As for the microbiomes role in this. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245625/ What can happen is that amyloid can deposit on the exterior of pilosebaceous glands, leading to amyloid associated alopecia. I had never understood why sebaceous glands would release trypsin before I learned about the role of amyloids in this. Among other proteins trypsin is able to break down amyloid depositions. So I'm assuming that trypsin is able to conceal evidence of amyloid induced alopecia in people whose sebaceous glands are able to produce sufficient levels of it. I am currently looking at a range of dietary interventions to try to alter my own production, deposition, and breakdown, of amyloids.

 

[Aidan Walsh]

To me, it's a microbiome imbalance. From the citizen science project on the microbiome, some 85 bacteria appears to be involved see the list here. High Blautia has the strongest association

I cannot see how this is involved at all even Ron Davis says people do not stay well. Are you 100% well now? Sounds more like a money gimic, one guy told me he spent over £16K in the UK