ditto.... Tramadol was a miracle, until it wasn't... Too hard on my stomach, so back to square one... When inflammation is down, I feel like a different person, or I should say, I finally feel how I am supposed to feel.Cool..... I've been saying for at least 7 years - autoimmune and inflammation is the core and that glutamate and dopamine dysregulation has something to do with it. Glad it's starting to be proven.
And as for mast cell the connection could be with the glutamate connection - NMDR dysfunction. Can cause one to be in sympathetic mode. But.... with me taking GABA has a paradox reaction. (It should modify glutamate.) Instead it hypes my sympathetic overdrive. It has been said that if one has a response to GABA (in either direction - good or bad) the blood brain barrier has been breeched. This isn't a good thing. Because harmful substances can go to your brain. I have found Tramadol to help with all my autonomic nervous system issues. It affects all the neurotransmitters and NMDA. (Not everyone has a positive response to Tramadol.) I stay very low on my dose and stop taking it when it quits working. Stay off a week or two and then go back on it. It somehow reboots and starts working at low doses again. I find using Bentyl - a mild muscle relaxer - helps in combination. Those two meds along with GastroCrom for mast cell have been my best RXs to date.