Mast cells, neuroinflammation, and pain in FM

[Merry]

This is a new research paper fromTheoharis C. Theoharides, Irene Tsilioni, and Mona Bawazeer
published 2 August 2019 in Frontiers in Cellular Neuroscience.

We hypothesize that thalamic mast cells contribute to inflammation and pain, by releasing neuro-sensitizing molecules that include histamine, IL-1β, IL-6 and TNF, as well as calcitonin-gene related peptide (CGRP), HK-1 and SP. These molecules could either stimulate thalamic nociceptive neurons directly, or via stimulation of microglia in the diencephalon. As a result, inhibiting mast cell stimulation could be used as a novel approach for reducing pain and the symptoms of FMS.

 

[Issie]

For sure my GastroCrom helps me. Mast cell medicine helped me go from wheelchair to having more of a life. Still not well.....but a turning point.