Muscle cell abnormalities

Cort

Founder of Health Rising and Phoenix Rising
Staff member
ME Research UK reports on an ME/CFS muscle fatigue study they funded:
http://www.meresearch.org.uk/news/muscle-cell-abnormalities/

The researchers' recently published paper can be found here:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122982
That's a good one! Thanks so much for sharing Merry :)

It's a small study but what a great findings - no energy production in ME/CFS cells! Somehow that seems to fit...:)

Stuff like this makes me tingle all over :)

Control cultures subjected to 16h EPS showed a significant increase in both AMPK phosphorylation and glucose uptake compared with unstimulated cells. In contrast, CFS cultures showed no increase in AMPK phosphorylation or glucose uptake after 16h EPS. However, glucose uptake remained responsive to insulin in the CFS cells pointing to an exercise-related defect. IL6 secretion in response to EPS was significantly reduced in CFS compared with control cultures at all time points measured.
Conclusion

mce-anchor
EPS is an effective model for eliciting muscle contraction and the metabolic changes associated with exercise in cultured skeletal muscle cells. We found four main differences in cultured skeletal muscle cells from subjects with CFS; increased myogenin expression in the basal state, impaired activation of AMPK, impaired stimulation of glucose uptake and diminished release of IL6. The retention of these differences in cultured muscle cells from CFS subjects points to a genetic/epigenetic mechanism, and provides a system to identify novel therapeutic targets.
 

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