NAD+ supplementation

[Ughhh]

Has anyone tried NAD+ supplementation. I came across it a while ago sold as anti aging in a variety of forms from injectables to patches to oral. I was reading last night about the kynurenine pathway Is it a trap? – paolo maccallini and NAD+ is the end product of the kynurenine pathway which seems intriguing to me to. Googling I found purveyors of NAD+ infusions for fibromyalgia so it's being marketed. I still have to read more as it's not cheap, but am curious to hear from people who have actually tried it.

 

[Meirav]

Niacinamide works just as well, a lot more affordable.
Small doses 50-100 grams a few times a day.
With minimal excipients, if any.

It took me a while to be able to take it,
I had to get all my other Bs (except B6) and minerals in first

 

[Learner]

I benefit consistently from either NAD+ or NMN in sublingual form, 150-225mg daily. Niacinamide reverses methylation and undies all the folate and B12 I'm taking.

I've done NAD infusions. They last about 36 hours vs 12-18 with the sublingual. They are expensive and difficult - making me jittery, nauseous, and give me diarrhea. They need a very slow drip speed, so take 3-4 hours to get 200mg in. Not worth the cost or effort.

The clinics offering it to addicts provide very high doses to support the addicts coming off their drugs. That's not us.

 

[Yoonreterna]

Thanks for raising this topic—NAD⁺ and its precursors are such a fascinating area for energy, aging, and recovery. I’ve experimented a bit myself and thought I’d share what I’ve found:

• Niacinamide can be a good, low-cost starting point. Small divided doses (like 50–100 mg a few times a day) seem to work best once your B vitamins and minerals are balanced.
• NMN or NAD⁺ sublingual forms are another option. For me, they’ve felt gentler and more manageable than infusions, which can be pricey and sometimes come with side effects like jitteriness or digestive upset.
• Infusions can last longer in effect, but the logistics (and cost) make them tough to sustain.

If anyone wants a deeper dive, I found this guide on NAD⁺ and NMN supplementation helpful for understanding the different approaches and how they support cellular energy.


Curious to hear what’s worked for others—especially if anyone’s tried combining niacinamide with diet or lifestyle changes that support NAD⁺ pathways.