'NAD: The Biological Rocket Fuel that Gives You Energy'

Remy

Administrator
NAD deficiency has long been implicated in numerous chronic inflammatory diseases. It's even being used successfully in drug rehabilitation programs now to ease withdrawal symptoms.

It kind of seems like a miracle so I'm curious why more studies haven't been done using it with the MECFS population.

At this point, it's really, really expensive. Treatments typically run $1000+ for each IV session and usually a minimum of 4 sessions are recommended for CFS. There are clinics that offer less expensive versions but (of course) the people hawking the more expensive BR+ (brain restoration) version insist that theirs is the only effective way to produce the NAD and the price won't come down until the compounding pharmacy that developed it has recouped their investment.

All that makes me scratch my head a little bit because it seems like they could recoup their investment faster if it worked and more people did it at a lower price too.

So is it really all that and a bag of chips? Or just another expensive rip off? I sure wish I knew!

From MindBody Medicine Center:

NAD stands for nicotinamide adenine dinucleotide, which is the chemical term for a molecule that reacts with oxygen in the mitochondria in every cell of your body in order to create energy so you can move, breathe, pump blood, digest food, think, and generally, live your life.

Lack of this essential cellular fuel is now recognized as a key feature of chronic fatigue, apathy, depression, anxiety, alcohol and drug addiction, weak immune system (infections and cancer), muscle pain and weakness, headaches, memory disturbance, sleep problems, focus and concentration defects and other chronic diseases. NAD deficiency may be an unrecognized epidemic of cellular disease.

NAD is an activated form of vitamin B3 which becomes a coenzyme when it is bound with hydrogen becoming NADH. Hydrogen, as in hydrogen bomb, is the explosive power that the body uses, along with oxygen, to make energy. Liquid hydrogen and liquid oxygen explode when blended together becoming the fuel that propels rockets into the sky. Hydrogen is so explosive that it must be safely inserted into a molecule so that it can be used by the body. NAD is the carrier for reactive hydrogen as it becomes NADH.
This is how it works. We eat carbohydrates, proteins and fats which provide the chemicals that enter the Citric Acid Cycle, a molecular roundabout that produces NADH. The NAD is now “loaded” with hydrogen (NADH) which in turn enters the electron transport chain in the mitochondria and is “sparked” with oxygen and the outcome is energy, or, ATP, along with water. ATP, or adenosine triphospate, is the fuel for the heart to beat, the muscles to contract and for every cellular energy requirement with in the 100 trillion cells of the body.

It is clear to see how important NADH is for the body as it is involved in every bodily function and catalyzes more than a thousand metabolic reactions in the organs and tissues. The heart uses the most NAD as it beats around 86,000 times daily. The brain consumes about one-third of all the energy produced by the body. Often an energy deficiency is first detected in the brain with poor concentration, difficulty focusing, and attention deficit. If the energy shortage lasts long enough, brain neurons cannot synthesize neurotransmitters, the molecules of consciousness, such as serotonin, dopamine, and noradrenaline, and we experience anxiety, depression, sleep disturbance and other mood changes.

Let us take a look at some of the functions of NADH in the body:
  • Increases energy in heart cells
  • Increases energy in brain cells
  • Protects and repairs DNA, reducing DNA mutations which contribute to atherosclerosis, cancer, immunodeficiency, rheumatoid arthritis, and much more
  • The “most powerful antioxidant” in the body according to Dr. Richard Passwater in his book NADH-The Energizing Coenzyme
  • Lowers cholesterol
  • Lowers blood pressure
  • Strengthens the immune system
  • Stimulates production of dopamine, serotonin, and noradrenaline, thereby improving moods
  • Stimulates nitric oxide production, thereby improving blood flow in the body
Research has shown the following medical conditions to improve with NAD therapy:
  • Chronic fatigue
  • Muscle pain and weakness
  • Joint pain and stiffness
  • Headaches
  • Depression
  • Anxiety
  • Alcohol and drug addiction
  • Diabetes
  • Sleep disturbance
  • Memory loss (forgetfulness)
  • Attention deficit
  • Fevers, sore throats and swollen lymph glands
  • Parkinson’s disease
  • Cancer

Research has also shown that NAD can provide the following benefits in “healthy” people:
  • Increased physical energy
  • Improved mental performance
  • Improved response to short term sleep deprivation
  • Reduce the effects of jet lag
  • Enhance libido
  • Anti-aging

Since NAD is so fundamental to good health, how is it that we can become deficient in this powerful molecule?

First of all, the vitamins, minerals, complex carbohydrates, proteins and fats come from our diet and provide the building blocks to citric acid cycle energy production. If any one of the nutritional factors is low, energy production is weakened. Since oxygen is just as important as hydrogen in cellular energetics, lack of exercise and shallow breathing due to stress are common factors that can reduce the amount of oxygen at the cell level. And finally the enzymes that catalyze the citric acid cycle are often inhibited or destroyed by chemical or physical toxins that create oxidative, or free radical, damage.

Free radical damage comes from cigarette smoke, drugs, radio waves from cell phones and wi-fi, and the myriad chemicals found in all humans at this time on earth, including phalates, parabens, pesticides, styrene, benzene, toluene, and thousands more. For example, medical scientists now widely believe that Alzheimer’s dementia and Parkinson’s disease share the common feature of nerve cell degeneration due to impairment of the ATP producing enzymes with the citric acid cycle and mitochondria.

However, there is more than acquired NAD deficiency, due to poor diet, chronic stress, sedentary living and toxin accumulation so common in our modern world – it may also be genetic for some people. Genetic NAD deficiency may be present at birth and appear in children as poor sleeping, behavioral problems, hyperactivity, impaired concentration, academic stress and underachievement.

Some people have been tired and depressed for as long as they can remember. For these people there is a greater tendency to try drugs and alcohol in order to improve energy and mood, and simply feel better, but the risk for addiction is high. I have treated several people addicted to drugs, alcohol or medical drugs such as benzodiazapenes, like Valium, Librium and Klonopin, with intravenous NAD, thereby eliminating the addiction and leading to improved energy and moods in the long run.

Genetic disorders in energy production are complex and the research is accumulating to help us understand this important issue. There may be a genetic polymorphism that reduces a gene coding for a mitochondrial protein. Since mitochondrial DNA is all received from the mother through the egg (no mitochondria are found in sperm) we can look to the maternal side for clues to energy production in the family history.

How do we diagnose NAD deficiency? Fatigue is often the first signal, but there are many conditions in the body that present as fatigue, such as low thyroid. The following clues are used in making a diagnosis of NAD deficiency:

Family history
  • Fatigue and depression, mainly on the mother’s side

Personal history
  • Fatigue and/or depression beginning early in life, such as childhood or teen years
  • Alcohol or drug addiction
  • Chronic fatigue any time in life
  • Depression and anxiety
  • Almost any chronic disease

Traditional blood tests
  • Lactic acid and pyruvate (blood):
    • Pyruvic acid comes from foods and supplies energy to the citric acid cycle when oxygen is present and alternatively ferments to produce lactic acid when oxygen is lacking (fermentation). Therefore elevated lactic acid or pyruvate may be a signal of NAD deficiency.

Specialty lab tests
  • Organic Acid testing (urine) is available from Genova Diagnostics, Great Plains Laboratory and Metametrix Clinical Laboratory:
    • Pyruvate and lactic acid can also be measured in a first-morning urine.
  • Citric Acid Cycle Intermediates are organic acids found in the urine that directly reflect CAC activity and when elevated indicate CAC dysfunction and reduced NADH. There are many metabolic reasons for elevated CAC intermediates.
  • Citric Acid Cycle Intermediates include the following:
    • Citric acid
    • Cis-Aconitic acid
    • Isocitric acid
    • Alpha-ketoglutaric acid
    • Succinic acid
    • Malic acid
    • Beta-hydroxy-beta-methylglutaric acid

How do you treat NAD deficiency?
First of all NAD is in many of the foods that we eat, but it is mostly lost in cooking and what little remains is broken down by the acid in our stomachs. Many research scientists have observed that NAD is oxidized and degraded before it is absorbed from the digestive tract. More recent studies have shown that NAD can be provided in a stabilized form and will increase ATP production in the body and in the brain, thereby offering hope to patients with neurodegenerative disorders.

For patients with severe NAD deficiencies, such as alcoholics or drug addicts, the intravenous form has been shown to be highly effective, usually eliminating the physical craving within three or four days and then producing a clarity of thinking with continued daily IV therapy. The cognitive and emotional improvement is likely due to increased production of neurotransmitters such as serotonin, noradrenalin and dopamine. Numerous studies have shown that IV NAD is highly beneficial for drug addicted patients, including those addicted to benzodiazepine medications like Valium, Librium and Klonopin.

Intravenous therapy for four to six days is often beneficial to people with chronic depression, often unresponsive to antidepressant therapies.

There is now a new form of oral NAD that is proving highly beneficial to patients with NAD deficiency and the widespread problems with adequate cellular energy production.

In the future, NAD therapy will likely prove beneficial for a range of common medical problems, including fatigue, jet lag, mood disorders, menopausal symptoms, obesity and more. Like aerobic exercise and healthy whole food nutrition, NAD therapy offers a foundational treatment that promotes health throughout the body.
 

Strike me lucky

Well-Known Member
Iherb had a sublingual version of nad not nadh. It was ok but nothing earth shattering. More like a caffeine boost??

Given iv would probably be very different.
 

Remy

Administrator
Iherb had a sublingual version of nad not nadh. It was ok but nothing earth shattering. More like a caffeine boost??

Given iv would probably be very different.
Yeah, the only oral version that is supposed to be efficacious is nicotinamide riboside. It's still really hard to take enough to make a difference though according to these people. If you can afford it, taking 1 g/day is probably a reasonable thing to do for your mitos.

Apparently high doses of plain niacin or nicotinamide are counterproductive too.
 

Strike me lucky

Well-Known Member
Yeah, the only oral version that is supposed to be efficacious is nicotinamide riboside. It's still really hard to take enough to make a difference though according to these people. If you can afford it, taking 1 g/day is probably a reasonable thing to do for your mitos.

Apparently high doses of plain niacin or nicotinamide are counterproductive too.
The brand i used a few years ago Now brand, i cant find it, i think it was 25mg dosage??
 

Remy

Administrator
The brand i used a few years ago Now brand, i cant find it, i think it was 25mg dosage??
Yes, I think you're right. It is discontinued now though.

I don't think we know if oral NAD can make it through the stomach acid. Obviously sublingual would help. I found a thread on another forum that lists some articles that I will post when back at computer.
 

doerfast

Member
Remy I did 3 days of NAD IV therapy and it didn't do a thing for me. They didn't even check my NAD levels before treatment. Why? Because they didn't even know how is why? Now you tell me, if you're in the NAD therapy business wouldn't you want to know HOW to measure NAD levels before you even got into the business? Duh Also if you are in the brain restoration business wouldn't you want to measure neurotransmitter levels via urine or platelets?

Also CoQ10 plays a huge part in the mitochondria and they don't even give CoQ10 in their IVs. Vitamin C and glutathione is about it. There is so much more to mitochondria repair than just NAD. Alpha Lipoic Acid, Acetyl L Carnitine, PQQ, pterostilbene and resveratrol to name just a few other nutrients that should be added into an IV treatment.

So to answer your questions:

"So is it really all that and a bag of chips? Or just another expensive rip off? I sure wish I knew!"

I'd say it's just another expensive rip off. May help the junkies but that's about it and yes you are right that it's outrageously expensive but you have to understand they are just catering to the wealthy families with junkies right now. They need to do clinical trials that measure neurotransmitters, NAD, nutrient and CoQ10 levels BEFORE and AFTER treatments if they want to get any respect in the healthcare.

Also all the NAD IV therapy clinics in the USA are spin offs of the William Hitt Center in Tijuana and if you read below he was a fraud and a Quack to say the least


“California attorney Jenelle C Prins, who has investigated Hitt, reports that "William Hitt does not have any undergraduate or medical degrees. In 1987 he was sued by the State of Texas, Case No 87 27882, for fraudulent practices. In sworn documents filed with the court, he admitted that he had no degrees of any type (except for one from what Hitt called 'a paper mill', known as Walden College)." Prins reports that the University of Colorado, where Hitt once claimed to have been awarded an MD in 1952, "has no record of him".

And what of that Nobel Prize? Hitt claims to have won the Nobel Peace Prize while a member of the International Physicians for the Prevention of Nuclear War. This is false, she says.

The International Physicians for the Prevention of Nuclear War corresponded with me and stated that Hitt had never been a member. Hitt has recently changed his story to say he was a member of the Mexican delegation to the International Physicians et al, but I checked this claim as well and it is also false."

Hitt claims to have won a "prestigious Eli Lily Award and several other awards. "I called Eli Lily and spoke with a woman there who researched Hitt's claim," says Prins. "First, Eli Lilly does not give out a prize. They do, however, provide grants, but no grant was ever awarded to Hitt."

"We learnt of his falsity when one of my clients returned from treatment for Hepatitis C in Mexico," says Prins. "When she went to her regular doctor to check her viral load, her levels were higher than when she went to Mexico." Prins says that in this and several other cases, "Hitt doctored test results"..."

The James Randi Educational Foundation
 
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Remy

Administrator
Remy I did 3 days of NAD IV therapy and it didn't do a thing for me. They didn't even check my NAD levels before treatment. Why? Because they didn't even know how is why? Now you tell me, if you're in the NAD therapy business wouldn't you want to know HOW to measure NAD levels before you even got into the business? Duh

Also CoQ10 plays a huge part in the mitochondria and they don't even give CoQ10 in their IVs. Vitamin C and glutathione is about it. There is so much more to mitochondria repair than just NAD. Alpha Lipoic Acid, Acetyl L Carnitine, PQQ, pterostilbene and resveratrol to name just a few other nutrients that should be added into an IV treatment.

So to answer your questions:

"So is it really all that and a bag of chips? Or just another expensive rip off? I sure wish I knew!"

I'd say it's just another expensive rip off. May help the junkies but that's about it and yes you are right that it's outrageously expensive but you have to understand they are just catering to the wealthy families with junkies right now. They need to do clinical trials that measure neurotransmitters, NAD, nutrient and CoQ10 levels BEFORE and AFTER treatments if they want to get any respect in the healthcare.

Also all the NAD IV therapy clinics in the USA are spin offs of the William Hitt Center in Tijuana and if you read below he was a fraud and a Quack to say the least


“California attorney Jenelle C Prins, who has investigated Hitt, reports that "William Hitt does not have any undergraduate or medical degrees. In 1987 he was sued by the State of Texas, Case No 87 27882, for fraudulent practices. In sworn documents filed with the court, he admitted that he had no degrees of any type (except for one from what Hitt called 'a paper mill', known as Walden College)." Prins reports that the University of Colorado, where Hitt once claimed to have been awarded an MD in 1952, "has no record of him".

And what of that Nobel Prize? Hitt claims to have won the Nobel Peace Prize while a member of the International Physicians for the Prevention of Nuclear War. This is false, she says.

The International Physicians for the Prevention of Nuclear War corresponded with me and stated that Hitt had never been a member. Hitt has recently changed his story to say he was a member of the Mexican delegation to the International Physicians et al, but I checked this claim as well and it is also false."

Hitt claims to have won a "prestigious Eli Lily Award and several other awards. "I called Eli Lily and spoke with a woman there who researched Hitt's claim," says Prins. "First, Eli Lilly does not give out a prize. They do, however, provide grants, but no grant was ever awarded to Hitt."

"We learnt of his falsity when one of my clients returned from treatment for Hepatitis C in Mexico," says Prins. "When she went to her regular doctor to check her viral load, her levels were higher than when she went to Mexico." Prins says that in this and several other cases, "Hitt doctored test results"..."

The James Randi Educational Foundation
Thanks for the info! I ultimately decided against it. But I am sorry to hear it didn't help you.
 

doerfast

Member
Yeah, the only oral version that is supposed to be efficacious is nicotinamide riboside. It's still really hard to take enough to make a difference though according to these people. If you can afford it, taking 1 g/day is probably a reasonable thing to do for your mitos.

Apparently high doses of plain niacin or nicotinamide are counterproductive too.
Source Naturals makes a 25 mg NAD sublingual tablet of 60 per bottle (Coenyzmated B3) and that's more than what the compound pharmacy that the NAD IV center I went to uses. Theirs was only 15mg at $40 plus shipping. You can get Source Naturals for like $15 off of ebay

I know those IV clinics give 750-1000 mg per day so if a person took 30 sublingual tablets per day or half a bottle a day that's like $7.50 a day compared to $1000-1300 a day. Yes sublingual isn't as good as straight into the vein but I bet you'll get at least 500 mg a day absorbed.

ENADA also makes a 5, 10 and 20 mg NADH tablet
 
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doerfast

Member
Thanks for the info! I ultimately decided against it. But I am sorry to hear it didn't help you.
Oh after maybe $15,000 worth it might have helped the Chronic Fatigue but I don't know because they were telling me about another patient who came in for brain fog and short term memory loss and he did like 12-15 days and didn't really clear up his problem.
 

doerfast

Member
Thanks for the info! I ultimately decided against it. But I am sorry to hear it didn't help you.
I had my NAD levels checked here just lately AFTER the 3 days of IV therapy and it was still at only 52 which is very low. So either mine was incredibly low to begin with or those NAD IV therapy clinics are using useless NAD. I've attached the NAD therapy manual that explains how to measure NAD levels. You need to have your latic and pyruvate acid levels drawn then calculated out for the NAD levels (starts at page 56). The South Africans are the pioneers in NAD therapy
 

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doerfast

Member
Source Naturals makes a 25 mg NAD sublingual tablet of 60 per bottle (Coenyzmated B3) and that's more than what the compound pharmacy that the NAD IV center I went to uses. Theirs was only 15mg at $40 plus shipping.

I know those IV clinics give 750-1000 mg per day so if a person took 30 sublingual tablets per day or half a bottle a day that's like $7.50 a day compared to $1000-1300 a day. Yes sublingual isn't as good as straight into the vein but I bet you'll get at least 500 mg a day absorbed.

ENADA also makes a 5, 10 and 20 mg NADH tablet
This is why I'm going to start taking 30 Co-Enzymated B-3 sublingual tablets a day along with HEEL CoEnzyme Compositum tablets:


"NAD Therapy is usually referring to IV Therapy, but there are supplements one can take if you are not able to get to a clinic for the IV Therapy. An internet search will find NAD supplements. IV NAD Therapy seems to be the quick miracle solution to help through serious illness or addiction, but home supplementation of a good Co-Enzymated B-3, over a longer period of time can be effective as well.

Addressing NED obviously cures many ailments and addictions, so if one is facing any of the conditions listed in this article, NAD Therapy, or at least home mega dose Vitamin Therapy should be indicated."

http://realgoodnews.com/healthenvironment/miracle-cure-for-addiction-depression-ptsd-and-chronic-illness/
 
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doerfast

Member
NAD deficiency has long been implicated in numerous chronic inflammatory diseases. It's even being used successfully in drug rehabilitation programs now to ease withdrawal symptoms.

It kind of seems like a miracle so I'm curious why more studies haven't been done using it with the MECFS population.

At this point, it's really, really expensive. Treatments typically run $1000+ for each IV session and usually a minimum of 4 sessions are recommended for CFS. There are clinics that offer less expensive versions but (of course) the people hawking the more expensive BR+ (brain restoration) version insist that theirs is the only effective way to produce the NAD and the price won't come down until the compounding pharmacy that developed it has recouped their investment.

All that makes me scratch my head a little bit because it seems like they could recoup their investment faster if it worked and more people did it at a lower price too.

So is it really all that and a bag of chips? Or just another expensive rip off? I sure wish I knew!

From MindBody Medicine Center:

NAD is not that expensive I checked on Alibaba with many companies that sell the raw powder which I bet 99.9% of the compounding pharmacies here in the USA get theirs from. Springfield Wellness just started the whole NAD IV thing in the USA as they were the only ones doing it so they jacked the prices way up and then started basically training other Docs.

Now there is a guy in Carmel IN starting his own little franchise selling it at $250K each. I've worked in the healthcare since 1992 and can tell you that the material and supplements they use cost them less than $100 Max a day probably more like 50-60. Sodium Chloride 0.09% NS bag 750ml cost like $20-25, NAD 1000mg powder diluted down then injected into the bag cost probably less than $15 beings it's bought in bulk, unless they are getting the whole IV bag already loaded from the compound pharmacy. Either way with amino acids, tyrosine, 5HTP, Vitamin C, Glutathione etc. you're not looking at more than $100 and that's probably pushing the high side.
 
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Remy

Administrator
NAD is not that expensive I checked on Alibaba with many companies that sell the raw powder which I bet 99.9% of the compounding pharmacies here in the USA get theirs from. Springfield Wellness just started the whole NAD IV thing in the USA as they were the only ones doing it so they jacked the prices way up and then started basically training other Docs.

Now there is a guy in Carmel IN starting his own little franchise selling it at $250K each. I've worked in the healthcare since 1992 and can tell you that the material and supplements they use cost them less than $100 Max a day probably more like 50-60. Sodium Chloride 0.09% NS bag 750ml cost like $20-25, NAD 1000mg powder diluted down then injected into the bag cost probably less than $15 beings it's bought in bulk, unless they are getting the whole IV bag already loaded from the compound pharmacy. Either way with amino acids, tyrosine, 5HTP, Vitamin C, Glutathione etc. you're not looking at more than $100 and that's probably pushing the high side.
I live in Indiana so am familiar with the practice of which you speak...
 

doerfast

Member
I live in Indiana so am familiar with the practice of which you speak...
I spoke with a Doc up in Vancouver CA and he's doing NAD IV therapy and also adds CoQ10 at only $500 a day so that right there shows you these clinics in the USA are charging outrageous prices. Even that Canadian Doc said that was very expensive and you know that he's making a good profit at $500 so I'd say my estimates of less than $100 a day is probably about right on their cost. Maybe when the wealthy junkies start slowing down they'll lower the prices as I know heroin has hit the rich kids hard. Life must be too tough for them huh?

Remy there is actually two clinics in Carmel, IN doing NAD.
 

Learner

Active Member
I hesitate to get involved here, but am interested in the topic.

I have found absolutely no benefit from nicotinamide riboside, even ramping up the dose, but I know that studies have shown it definitely helps some people.

However, Enada NADH helps me. I keep it in my wallet and in my car, and pop 1-2 10mg sublingual tablets when I need to function or focus for an hour or two when I'm not feeling up to the task. It improves my energy within 10 minutes.

The folks who push NR will say NADH can't be properly digested and assimilated, but I've found sublingually it works just fine.

My friend and I tried both side by side one day, and we found NADH did nothing for her, where the NR did, and for me, it was the opposite.

I just had a discussion about this with a chemistry PhD friend, and she said there are a lot of reasons for these differences - we're unique individuals. Seems like all the variations of niacin, NAD, etc. have merit, depending on the individual situation...


When I was doing very poorly, my ND, who is very competent and careful, considered doing either an AMP or an NAD IV for me, but things turned around for me before we needed to go there. They were definitely last resort offerings, not first line treatments.

I have had dramatic results with various IV therapies. Unfortunately, the prices I see for the range of IVs are more in the $200-500 range vs $100. I've been at this long enough to know what's some of the ingredients cost as well as the fixed costs involved, at least on the west coast, to doubt anyone can offer a quality IV for $100. If so, I'd be suspicious... the price for vitamin C alone has gone up 5 times in the past 6 months...

IV therapy can be extremely powerful, when used sensibly, with high quality ingredients in a sterile environment.

It pays to be a wary consumer, ask questions, and understand the science behind what is being offered.

I worry that people cavalierly doing things to make a buck could result in limiting access or causing costs to skyrocket for treatments my fellow patients and I have gotten great benefit from...and keeping us sick.
 

doerfast

Member
I spoke with a Doc up in Vancouver CA and he's doing NAD IV therapy and also adds CoQ10 at only $500 a day so that right there shows you these clinics in the USA are charging outrageous prices. Even that Canadian Doc said that was very expensive and you know that he's making a good profit at $500 so I'd say my estimates of less than $100 a day is probably about right on their cost. Maybe when the wealthy junkies start slowing down they'll lower the prices as I know heroin has hit the rich kids hard. Life must be too tough for them huh?

Remy there is actually two clinics in Carmel, IN doing NAD.
I spoke with a Doc up in Vancouver CA and he's doing NAD IV therapy and also adds CoQ10 at only $500 a day so that right there shows you these clinics in the USA are charging outrageous prices. Even that Canadian Doc said that was very expensive and you know that he's making a good profit at $500 so I'd say my estimates of less than $100 a day is probably about right on their cost. Maybe when the wealthy junkies start slowing down they'll lower the prices as I know heroin has hit the rich kids hard. Life must be too tough for them huh?

Remy there is actually two clinics in Carmel, IN doing NAD.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346380/
 

doerfast

Member
Well after much further research I've found out from 4 different Ph.D Biochemist that NAD supplement does NOT cross the mitochondria inner membrane so it's not therapeutic at ALL given via IV as these NAD IV therapy clinics are doing. But I've shown this information to several of these clinics and one even comes back and STILL says that what they are doing INCREASES NAD levels in the mitochondria.

But as I've shown William Hitt was a true quack and fraud so it doesn't surprise me that his cronies are the same. It's all about the MONEY people but the sad thing is these families are shelling out $12-17,000+ when it's probably just the amino acids, glutathione, Vitamin C, etc. that is curing these addicts. Something they could get for less than $200 a day at a place like IV Express, etc.

Now if they were giving one of these like shown on this site via IV I'd say it would increase the NAD levels INSIDE the mito.

The following are precursors (raw materials) from which NAD+ can be produced:
https://selfhacked.com/2016/12/27/nad-important-increase/

(Note: See below how MONEY is the driving force as these two BioChemist each push their own products. One Nicotinamide Riboside and the other is pushing NADH supplement)

Hello

I think it’s worse than that. NAD+ and NADH have two phosphates, so they are not cellularly available. These compounds are almost certainly converted to NR, which is taken up by cells.

NR is orally available. We do not recommend IV NAD+.

Pure NR chloride can be purchased from prohealthspan.com

Charles Brenner Ph.D
University of Iowa


Hello,

NAD therapy does nothing because NAD+ (the oxidized form of NADH ) does not enter the cell. How should it exhibit an effect if it does not reach the inside of the cell?

NADH is the only moleciule that passes the cell membrane and increases the ATP energy in the cell. In the cell NADH is oxidized to NAD* and water. Hence NADH is the only molecule able to increase intracellular levels of NAD+

I have never ever read such biochemical Non-Sense. NR is a charged molecule and a charged molecule can not penetrate a lipid membrane such as the cell membrane.

We have proven scientifically that NADH penetrates the cell membrane and increases ATP in the cell (see attached publication). On Fig. 4 you can see that only NADH but neither Nicotinamide nor NAD+ goes into the cell and increases ATP energy there.


Regards,

Univ. Prof. Dr. Joerg George Birkmayer
President & CEO
NADH Handels GmbH
Schwarzspanierstreet 15
A – 1090 Vienna, AUSTRIA
Tel: ++43-1-361699610
Fax:++43-1-361699611
info@birkmayer-nadh.com
www.birkmayer-nadh.com


A mammalian mitochondrial NAD transporter has yet to be found [16, 44], and it has been shown that NAD is unable to cross the mitochondrial membrane [6], such as in isolated liver mitochondria [47]."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683958/#R16



NADH cannot simply pass into mitochondria for oxidation by the respiratory chain, because the inner mitochondrial membrane is impermeable to NADH and NAD+. The solution is that electrons from NADH, rather than NADH itself, are carried across the mitochondrial membrane. One of several means of introducing electrons from NADH into the electron transport chain is the glycerol 3-phosphate shuttle (Figure 18.37). The first step in this shuttle is the transfer of a pair of electrons from NADH to dihydroxyacetone phosphate, a glycolytic intermediate, to form glycerol 3-phosphate.This reaction is catalyzed by a glycerol 3-phosphate dehydrogenase in the cytosol. Glycerol 3-phosphate is reoxidized to dihydroxyacetone phosphate on the outer surface of the inner mitochondrial membrane by a membrane-bound isozyme of glycerol 3-phosphate dehydrogenase. An electron pair from glycerol 3-phosphate is transferred to a FAD prosthetic group in this enzyme to form FADH2. This reaction also regenerates dihydroxyacetone phosphate.
 
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doerfast

Member
Remy I did 3 days of NAD IV therapy and it didn't do a thing for me. They didn't even check my NAD levels before treatment. Why? Because they didn't even know how is why? Now you tell me, if you're in the NAD therapy business wouldn't you want to know HOW to measure NAD levels before you even got into the business? Duh Also if you are in the brain restoration business wouldn't you want to measure neurotransmitter levels via urine or platelets?

Also CoQ10 plays a huge part in the mitochondria and they don't even give CoQ10 in their IVs. Vitamin C and glutathione is about it. There is so much more to mitochondria repair than just NAD. Alpha Lipoic Acid, Acetyl L Carnitine, PQQ, pterostilbene and resveratrol to name just a few other nutrients that should be added into an IV treatment.

So to answer your questions:

"So is it really all that and a bag of chips? Or just another expensive rip off? I sure wish I knew!"

I'd say it's just another expensive rip off. May help the junkies but that's about it and yes you are right that it's outrageously expensive but you have to understand they are just catering to the wealthy families with junkies right now. They need to do clinical trials that measure neurotransmitters, NAD, nutrient and CoQ10 levels BEFORE and AFTER treatments if they want to get any respect in the healthcare.

Also all the NAD IV therapy clinics in the USA are spin offs of the William Hitt Center in Tijuana and if you read below he was a fraud and a Quack to say the least


“California attorney Jenelle C Prins, who has investigated Hitt, reports that "William Hitt does not have any undergraduate or medical degrees. In 1987 he was sued by the State of Texas, Case No 87 27882, for fraudulent practices. In sworn documents filed with the court, he admitted that he had no degrees of any type (except for one from what Hitt called 'a paper mill', known as Walden College)." Prins reports that the University of Colorado, where Hitt once claimed to have been awarded an MD in 1952, "has no record of him".

And what of that Nobel Prize? Hitt claims to have won the Nobel Peace Prize while a member of the International Physicians for the Prevention of Nuclear War. This is false, she says.

The International Physicians for the Prevention of Nuclear War corresponded with me and stated that Hitt had never been a member. Hitt has recently changed his story to say he was a member of the Mexican delegation to the International Physicians et al, but I checked this claim as well and it is also false."

Hitt claims to have won a "prestigious Eli Lily Award and several other awards. "I called Eli Lily and spoke with a woman there who researched Hitt's claim," says Prins. "First, Eli Lilly does not give out a prize. They do, however, provide grants, but no grant was ever awarded to Hitt."

"We learnt of his falsity when one of my clients returned from treatment for Hepatitis C in Mexico," says Prins. "When she went to her regular doctor to check her viral load, her levels were higher than when she went to Mexico." Prins says that in this and several other cases, "Hitt doctored test results"..."

The James Randi Educational Foundation
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