Strike me lucky
Well-Known Member
I just thought i would post this as nsaids such as celebrex are being mentioned as a treatment along with antivirals for fibro etc.
Although celebrex has a lower risk of stomache issues, naproxen has a much better cardiovascular safety profile than celebrex.
So one has to weigh up the risk to benefit ratio, but atleast there are alternatives. Below is a link from wikipedia but easy to find similar info online if one wants more references.
Adverse effects[edit]
COX-2 selective and nonselective NSAIDs have been linked to increases in the number of serious and potentially fatal cardiovascular events, such as myocardial infarctions and strokes. Naproxen is, however, associated with the smallest overall cardiovascular risks.[7][8] Cardiovascular risk needs to be taken into account when prescribing any non-steroidal, anti-inflammatory drug. The drug had roughly 50% of the associated risk of stroke as compared with ibuprofen and was also associated with a reduced number of myocardial infarctions as compared to control groups.[7]As with other non-COX-2 selective NSAIDs, naproxen can cause gastrointestinal problems, such as heartburn, constipation, diarrhea, ulcers and stomach bleeding.[9] Persons with a history of ulcers or inflammatory bowel disease should consult a doctor before taking naproxen.
It was found that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular disease (CVD) risk, whereas other high-dose NSAID regimens had only transient effects on platelet COX-1 and were associated "with a small but definite vascular hazard". Conversely, naproxen was associated with higher rates of upper gastrointestinal bleeding complications in comparison to other NSAIDs.[8]
NSAID painkillers, such as naproxen, may interfere with and reduce the efficacy of SSRI antidepressants
http://en.wikipedia.org/wiki/Naproxen
Although celebrex has a lower risk of stomache issues, naproxen has a much better cardiovascular safety profile than celebrex.
So one has to weigh up the risk to benefit ratio, but atleast there are alternatives. Below is a link from wikipedia but easy to find similar info online if one wants more references.
Adverse effects[edit]
COX-2 selective and nonselective NSAIDs have been linked to increases in the number of serious and potentially fatal cardiovascular events, such as myocardial infarctions and strokes. Naproxen is, however, associated with the smallest overall cardiovascular risks.[7][8] Cardiovascular risk needs to be taken into account when prescribing any non-steroidal, anti-inflammatory drug. The drug had roughly 50% of the associated risk of stroke as compared with ibuprofen and was also associated with a reduced number of myocardial infarctions as compared to control groups.[7]As with other non-COX-2 selective NSAIDs, naproxen can cause gastrointestinal problems, such as heartburn, constipation, diarrhea, ulcers and stomach bleeding.[9] Persons with a history of ulcers or inflammatory bowel disease should consult a doctor before taking naproxen.
It was found that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular disease (CVD) risk, whereas other high-dose NSAID regimens had only transient effects on platelet COX-1 and were associated "with a small but definite vascular hazard". Conversely, naproxen was associated with higher rates of upper gastrointestinal bleeding complications in comparison to other NSAIDs.[8]
NSAID painkillers, such as naproxen, may interfere with and reduce the efficacy of SSRI antidepressants
http://en.wikipedia.org/wiki/Naproxen