Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multip

Discussion in 'Chronic Fatigue Syndrome (ME/CFS) Research' started by Who Me?, Feb 10, 2016.

  1. IrisRV

    IrisRV Well-Known Member

    Thank you! That's much more within the reach of my brain. It's interesting stuff. Lots of clues there. I appreciate you bringing all this to our attention. Great articles.
     
    Who Me? and RuthAnn like this.
  2. RuthAnn

    RuthAnn Well-Known Member

    I don't really understand this, but it led me to a link that makes me think that a calcium channel blocker would slow down the action of the NK cells. This isn't important to us, but it could be for people with GWI, as they have very high NK counts.

    If I have it backwards and an agonist would be the way to slow down NK cell activity, please let me know.
     
  3. IrisRV

    IrisRV Well-Known Member

    Are we talking about the standard calcium channel blocker used in heart conditions?
     
  4. RuthAnn

    RuthAnn Well-Known Member

    This is interesting, a constituent of St. John's Wort, hyperforin, may help to activate NK cells.

    I saw St. John's Wort mentioned to be good for viruses. Perforin activates NK cells, if one is deficient in perforin this could be the ticket. According to this paper it looks as if hyperforin accomplishes the same thing as perforin.

    http://www.fasebj.org/content/21/14/4101.full.pdf
     
    Who Me? and Strike me lucky like this.
  5. RuthAnn

    RuthAnn Well-Known Member

    Who Me? and Strike me lucky like this.
  6. Strike me lucky

    Strike me lucky Well-Known Member

    Interesting. I have heard st johns wort is effective for herpes viruses, i wonder if its because of its effects on nk function?
     
    Who Me? and RuthAnn like this.
  7. thisisqueenc

    thisisqueenc New Member

    I don't fully understand the nature of this article.

    Does the natural killer cell cause chronic fatigue syndrome? I know @weyland mentioned perforin is used by nk cells to kill viruses, but how does that cause chronic fatigue?

    I googled some more articles related to chronic fatigue syndrome and here is what I've found.
    https://www.webmd.com/chronic-fatigue-syndrome/default.htm
    https://www.healthline.com/health/chronic-fatigue-syndrome
    http://www.genetex.com/NKp46-antibody-N1C3-GTX115238.html
     
Loading...