Thank you! That's much more within the reach of my brain. It's interesting stuff. Lots of clues there. I appreciate you bringing all this to our attention. Great articles.NK cells need an influx of calcium in order to operate.
When they are lacking CD16 the CD38 no longer will make the calcium go into the NK cells.
It is a cluster of differentiation molecule found on the surface of natural killer cells,neutrophil polymorphonuclear leukocytes, monocytes and macrophages.These receptors bind to the Fc portion of IgG antibodies which then activates the NK cell forantibody-dependent cell-mediated cytotoxicity. A lack of CD16 in a given population of neutrophils may indicate prematurity, as could be caused by a left shift due to neutrophilic leukocytosis induced by tissue necrosis or bacterial infection."
So I don't know what would cause a lack of CD16 in NK cells, but as in the above paragraph, lack of CD16 in neutrophils has a listed cause. Although this paragraph may give another clue, lack of IgG antibodies on the NK cells.