Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multip

IrisRV

Well-Known Member
NK cells need an influx of calcium in order to operate.

When they are lacking CD16 the CD38 no longer will make the calcium go into the NK cells.

"CD16 :

It is a cluster of differentiation molecule found on the surface of natural killer cells,neutrophil polymorphonuclear leukocytes, monocytes and macrophages.[1]These receptors bind to the Fc portion of IgG antibodies which then activates the NK cell forantibody-dependent cell-mediated cytotoxicity. A lack of CD16 in a given population of neutrophils may indicate prematurity, as could be caused by a left shift due to neutrophilic leukocytosis induced by tissue necrosis or bacterial infection.[2]"

So I don't know what would cause a lack of CD16 in NK cells, but as in the above paragraph, lack of CD16 in neutrophils has a listed cause. Although this paragraph may give another clue, lack of IgG antibodies on the NK cells.
Thank you! That's much more within the reach of my brain. It's interesting stuff. Lots of clues there. I appreciate you bringing all this to our attention. Great articles.
 

RuthAnn

Well-Known Member
I'm saying that perforin production or release may be diminished by activation of beta adrenergic receptors on NK cells. Hyperadrenergic states are known to occur in dysautonomia.
I don't really understand this, but it led me to a link that makes me think that a calcium channel blocker would slow down the action of the NK cells. This isn't important to us, but it could be for people with GWI, as they have very high NK counts.

If I have it backwards and an agonist would be the way to slow down NK cell activity, please let me know.
 

IrisRV

Well-Known Member
I don't really understand this, but it led me to a link that makes me think that a calcium channel blocker would slow down the action of the NK cells. This isn't important to us, but it could be for people with GWI, as they have very high NK counts.

If I have it backwards and an agonist would be the way to slow down NK cell activity, please let me know.
Are we talking about the standard calcium channel blocker used in heart conditions?
 

Strike me lucky

Well-Known Member
This is interesting, a constituent of St. John's Wort, hyperforin, may help to activate NK cells.

I saw St. John's Wort mentioned to be good for viruses. Perforin activates NK cells, if one is deficient in perforin this could be the ticket. According to this paper it looks as if hyperforin accomplishes the same thing as perforin.

http://www.fasebj.org/content/21/14/4101.full.pdf
Interesting. I have heard st johns wort is effective for herpes viruses, i wonder if its because of its effects on nk function?
 

thisisqueenc

New Member
I don't fully understand the nature of this article.

Does the natural killer cell cause chronic fatigue syndrome? I know @weyland mentioned perforin is used by nk cells to kill viruses, but how does that cause chronic fatigue?

I googled some more articles related to chronic fatigue syndrome and here is what I've found.
https://www.webmd.com/chronic-fatigue-syndrome/default.htm
https://www.healthline.com/health/chronic-fatigue-syndrome
http://www.genetex.com/NKp46-antibody-N1C3-GTX115238.html
 

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