I've also had positive ANA 1:320 speckled with other tests negative. This seems to be pretty common with autoimmune disorders that there are many years of negative tests, it has to be followed over time both symptoms and follow up testing. I tend to think my issues are autoimmune bc I feel much better on steroids. I also like indomethacine which is an nsaid. I've also begun to have issues with my skin and rashes. Is it rosacea, is it a lupus rash, who knows but I have a dermatologist following it now. I've had a face rash in Oct, in Dec and again this week. Very weird stuff, the symptoms jump around and come and go.