I'm not sure how one would interpret "try this" as "this works for every me/ CFS patient". He made no such claim.
I'm interested in how you determined that methyl cobalamin caused a bad reaction - if you ruled out other "inactive" or active ingredients in the B12, and you weren't doing anything else new or different, then I'm interested in whether it was the methylation itself that caused a reaction - and in that case whether you are also allergic to sulfa since methylation involves sulfur. Also if you have the MTHFR genetic mutation affecting your ability to methylate B12 and folate on your own. Also if you have a similar issue with methylfolate? Thanks.
I suspect many of us have issues with sulfur which contribute to -or are caused by -the metabolic and immune issues of CFS. Sulphur plays an essential role in those processes.
http://www.thehealthyhomeeconomist.com/sulphur-the-forgotten-nutrient/ easily readable reference
http://benbest.com/health/Meth.html. Complex description of methylation process with diagrams
Really nice summary:
B12 (cobalamin) is a vitamin “family” with five unique family members that each do different things: a) cyanocobalamin; b) hydroxycobalamin; c) adenosylcobalamin; d) glutathionylcobalamin; e) methylcobalamin. Out of the B12 family, only Methyl-B12 has the ability to activate the methionine/homocysteine biochemical pathway directly. It is this pathway that is responsible for the body’s entire sulfur-based detoxification system. It is this pathway that is responsible for the formation of S-adenosylmethionine (SAMe), the universal methyl donor. It is this pathway that is responsible for the formation of homocysteine, the “crossroads” molecule that is responsible either to reform methionine and SAMe or create cysteine, taurine, and glutathione. Glutathione is the body’s primary intracellular antioxidant and is responsible for many detoxification reactions, most notably those that involve the binding and removal of mercury, lead, cadmium, arsenic, nickel, tin, antimony, and many other lesser-known heavy metals that also bind to glutathione’s sulfur group.
Methyl-B12 is closely allied with the folic acid biochemical pathway. A precursor folic acid molecule must interact with the enzyme MTHFR (methylenetetrahydrofolic acid) to become 5-methyltetrahydrofolic acid, the molecule that donates its methyl group to B12 so it can become Methyl-B12. Unfortunately, many children have a defect in this enzyme.
![ME/CFS lecture | Dr Nancy Klimas | 2011 [Chronic Fatigue Syndrome / SEID / New Zealand] - YouTube](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
