Study: Cellular bioenergetics is impaired in patients with chronic fatigue syndrome

Discussion in 'Chronic Fatigue Syndrome (ME/CFS) Research' started by nanobug, Feb 27, 2018.

  1. nanobug

    nanobug Member

    From the paper:

    "Results showed consistently lower measures of OXPHOS parameters in PBMCs taken from CFS patients compared with healthy controls. [...] While many of the parameters differed between the CFS and control cohorts, maximal respiration was determined to be the key parameter in mitochondrial function to differ between CFS and control PBMCs due to the consistency of its impairment in CFS patients found throughout the study (p≤0.003). The lower maximal respiration in CFS PBMCs suggests that when the cells experience physiological stress they are less able to elevate their respiration rate to compensate for the increase in stress and are unable to fulfil cellular energy demands. The metabolic differences discovered highlight the inability of CFS patient PBMCs to fulfil cellular energetic demands both under basal conditions and when mitochondria are stressed during periods of high metabolic demand."

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655451/
     
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