Mats Lindström
Active Member
Herpes found in 4 of 4 patients with symtoms of viral meningoencephalitis
In a recently study researcher screened for viral DNA in cerebrospinal fluid samples using NGS technology to diagnose CNS viral infections. They collected CSF samples from four cases with clinically suspected viral meningoencephalitis. DNA extracted from the samples was analyzed with next generation sequencing* (NGS), and the results were further validated using PCR. Herpes simplex virus 1 (HSV-1) was detected in the CSF of two patients, HSV-2 and human herpes virus type 3 (HHV-3, VZV) in the CSF of two other patients separately.
Source
Discussion
This study indicates that active herpes is more common in the central nervous system than previously thought. Routine laboratory tests are generally not helpful in the diagnosis of HSV but may show evidence of infection or detect renal disease. The diagnosis can be confirmed only by means of PCR or brain biopsy.
Source
There are eight different kinds of herpes viruses and IgG is important!
Physicians are taught that IgG results have no bearing on whether an infection is active or not but Dr. Dantini, Dr. Lerner and Dr. Montoya. All believe that very high IgG levels in the presence of illness often do reflect an active infection. Dr. Dantini believes antibody titers about 4 times what is considered normal – reflect an active infection in a person with the symptoms of ME/CFS/FM.
Source
Today's technology is not sufficient to determine if a patient has herpes in active form in the central nervous system. Even taking samples in both serum and cerebrospinal fluid, there is still great uncertainty.
Source
*Next generation sequencers (NGS) to detect viruses
Since last century, a number of different virus discovery methods, based on cell culture inoculation, sequence-independent PCR have been used for identification of a variety of viruses. However, the recent emergence and commercial availability of next-generation sequencers (NGS) has entirely changed the field of virus discovery.
By the late-1950s, it was generally believed that most of the human pathogenic viruses had been discovered, but the emergence of a number of previously unknown viruses [Hepatitis viruses, Hantavirus, human immunodeficiency virus, Marburg virus, severe acute respiratory syndrome (SARS), Coronavirus Ebola virus] during the later part of the century strongly challenged this belief.
Source
In a recently study researcher screened for viral DNA in cerebrospinal fluid samples using NGS technology to diagnose CNS viral infections. They collected CSF samples from four cases with clinically suspected viral meningoencephalitis. DNA extracted from the samples was analyzed with next generation sequencing* (NGS), and the results were further validated using PCR. Herpes simplex virus 1 (HSV-1) was detected in the CSF of two patients, HSV-2 and human herpes virus type 3 (HHV-3, VZV) in the CSF of two other patients separately.
Source
Discussion
This study indicates that active herpes is more common in the central nervous system than previously thought. Routine laboratory tests are generally not helpful in the diagnosis of HSV but may show evidence of infection or detect renal disease. The diagnosis can be confirmed only by means of PCR or brain biopsy.
Source
There are eight different kinds of herpes viruses and IgG is important!
Physicians are taught that IgG results have no bearing on whether an infection is active or not but Dr. Dantini, Dr. Lerner and Dr. Montoya. All believe that very high IgG levels in the presence of illness often do reflect an active infection. Dr. Dantini believes antibody titers about 4 times what is considered normal – reflect an active infection in a person with the symptoms of ME/CFS/FM.
Source
Today's technology is not sufficient to determine if a patient has herpes in active form in the central nervous system. Even taking samples in both serum and cerebrospinal fluid, there is still great uncertainty.
Source
*Next generation sequencers (NGS) to detect viruses
Since last century, a number of different virus discovery methods, based on cell culture inoculation, sequence-independent PCR have been used for identification of a variety of viruses. However, the recent emergence and commercial availability of next-generation sequencers (NGS) has entirely changed the field of virus discovery.
By the late-1950s, it was generally believed that most of the human pathogenic viruses had been discovered, but the emergence of a number of previously unknown viruses [Hepatitis viruses, Hantavirus, human immunodeficiency virus, Marburg virus, severe acute respiratory syndrome (SARS), Coronavirus Ebola virus] during the later part of the century strongly challenged this belief.
Source
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