Ah, I see. This is the part that confused me:I am not saying they are the same disease. I said they might share a common root.
[my bolding]When you stop looking at these as separate diseases it will all start to make sense.
I'm still not convinced that the root is the same. There's a great deal more to ME than a serotonin issue. Serotonin has some effects on some body systems, but it doesn't explain many of the common features of ME. I can't see it as the root of ME.
That isn't to say that there may not be serotonin issues with some PWME, just that we don't know where the cause/effect relationships are. If I understand correctly, you are suggesting that serotonin/glutamate/dopamine problems are at the root of ME. I suggest that it is even more likely that neurological issues related to ME cause serotonin/glutamate/dopamine problems in some PWME. That is, the cause/effect could be the other way around.
If you are saying that depression-only patients and some cases of ME have some neurochemical problems in common, I will agree that that could be possible, but is unproven. Depression-only patients may have some features in common with many other diseases.
If we're looking for commonalities, we need better quality research than Michael Sharpe (a psychologist, not a biomedical scientist) using Oxford definition patients. A BPS bias combined with lack of biomedical training, and a very poor patient cohort does not produce reliable biomedical evidence on ME. His data could easily reflect the inclusion of depression-only patients in his research on what he calls cfs using the crap Oxford definition.
I think we agree that there may be some commonalities in neurochemical abnormalities between depression-only patients and some PWME.
Where we may need to agree to disagree is in causality, universality, and the quality of the currently available research on neurochemical dysfunction in ME.
That's just fine. We can interpret the available evidence differently and we can have different opinions as a result. The world would be a terrible place if we all agreed on everything.