MOTS-c is one of the more interesting peptides to read about because it’s actually encoded by mitochondrial DNA, which is pretty unusual.
I work with Peptides.io, and we recently looked into the research on it. The animal data around energy metabolism and AMPK is interesting, but the human evidence is still really early, so I’d be careful with some of the stronger claims being made online.
We put together a straightforward research summary here if it helps:
MOTS-c is an early-stage peptide from your cells' power plants, studied for energy. It is not FDA-approved.
peptides.io
I’d also be interested to hear if anyone here has found good human data beyond the newer clinical trials.