Rain and snow tend to be leveling for me. Profoundly leveling - above and beyond the already intense fatigue I manage. And I really do mean profound, and leveling. This has been true for decades - well before my ME became severe enough to be bedbound. Even when my ME was mild and moderate - when I could often function well enough that the outside world had no idea of the suffering behind the scenes - I could be laid flat by weather shifts. Precipitation causes the most exaggerated response; it will be always worth if wind and a temperature descent accompany it. Does anyone else experience this overpowering reaction to weather changes?