The High Dose B1/Thiamine Survey?

Tina

Well-Known Member
Was this survey ever conducted? I am currently interested in the thiamine deficiency angle.
http://www.healthrising.org/blog/2013/07/19/the-high-dose-b-1-thiamine-supplementation-survey-fibromyalgia-chronic-fatigue-syndrome/

I came across the following in an article:
As the possible pathogenic factor of impaired glucose metabolism, altered thiamine metabolism should precede the alterations of brain glucose metabolism and subsequent cognitive deficits.
http://www.sciencedirect.com/science/article/pii/S0301008213000531
What hits me is the "impaired glucose metabolism" that comes up time and time again.
I have said for years that when I have exceeded my energy envelope or I am experiencing PEM my brain feels "dehydrated," but maybe starved is a better word both literally and figuratively.
 

rebar

Active Member
I took high dose B1 soon after Cort's article. I took 1000 mg and had a response after 3 days, the morning of the 3rd day I awoke calm and feeling rested, it helped conciderably for about 2 months then stopped working. I've since retried it a couple of times to no avail. I've got ME.
 

Merida

Well-Known Member
I have an article found at solace nutrition.com by Bruce Cohen, pediiatric neurologist and mito specialist, and Gold.
" Mitochondrial Cytopathy in Adults : What We Know So Far." ( in Cleveland Clinic Journal of Medicine, July 2001. Vol. 68 (7)

The authors included specific supplements, vitamins, and dosage. Here they are:
Coenzyme Q10 5-15 mg/kg in divided doses
L- carnitine. 30-100 mg/kg in divided doses
Thiamine. 100-800 mg
Riboflavin (B2). 400 mg
Niacinamide(B3). 100-500mg Avoid niacin form which can cause flushing
Folate 1-10 mg
Vitamin E. 400-1200 IU divided doses ( may interfere with CoQ10 absorption)
Selenium. 25-50 micrograms
Lipoic acid. 200-600 mg. in divided doses

Prednisone 5-60 mg. ( use sparingly, withdrawal can lead to symptom recurrence)
 

Cort

Founder of Health Rising and Phoenix Rising
Staff member
I took high dose B1 soon after Cort's article. I took 1000 mg and had a response after 3 days, the morning of the 3rd day I awoke calm and feeling rested, it helped conciderably for about 2 months then stopped working. I've since retried it a couple of times to no avail. I've got ME.
Isn't that something. That pattern - something works and then just stops working - does seem rather ME'ey
 

Cort

Founder of Health Rising and Phoenix Rising
Staff member
Was this survey ever conducted? I am currently interested in the thiamine deficiency angle.
http://www.healthrising.org/blog/2013/07/19/the-high-dose-b-1-thiamine-supplementation-survey-fibromyalgia-chronic-fatigue-syndrome/

I came across the following in an article:

http://www.sciencedirect.com/science/article/pii/S0301008213000531
What hits me is the "impaired glucose metabolism" that comes up time and time again.
I have said for years that when I have exceeded my energy envelope or I am experiencing PEM my brain feels "dehydrated," but maybe starved is a better word both literally and figuratively.
Impaired glucose metabolism - glycolysis - sounds very much like what Naviaux found isn't it? I should know - I wrote the blog (lol) - but I don't remember.
 

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