Hari
Active Member
Dear All,
In my earlier posts I mentioned that Noni Juice helped me to gain energy, but I did not know why. With the interest to help all of you to know why, and encourage you to try noni juice under the supervision of your physician. I searched PubMed database for noni and mitochondria.
Morinda Citrifolia is scientific name for Noni.
Please note the studies are not done for FMS / CFS. But I find relevance to FMS / CFS based on other related information.
Noni and Mitochoandria
Here is the explanation by Dr. Mayhill: http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure
Here is the scientific evidence: Morinda Citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders.
http://www.apocpcontrol.org/paper_file/issue_abs/Volume16_No4/1675 8.14 Caramel Simone [Letter to Editor].pdf
Extract from above link:
QBS tests, by evaluating both parenchymal and microcirculatory parameters, confirm the already well known anti-oxidant properties of Noni fruit and other peculiar properties such as (a) diminishing/normalizìng the tissue acidosis, (b) re-equilibrating the acid-basic balance, (c) ameliorating/normalizing the mitochondrial redox activity as well as the tissue oxygenation, the microcirculatory flow motion and the metabolism as a whole
***** *****
I also found that noni juice reduces oxidative stress. Outcome of oxidative stress for FMS / CFS could be PEM - Post Exertion Malaise.
Oxidative stress may cause PEM:
1. http://solvecfs.org/post-exertional-malaise-cause-and-effect/
Extract from the above page:
....Studies have found that peak oxygen consumption and maximum capacity for oxygen consumption are lower in CFS patients than controls
......Research has also suggested that muscle energy metabolism is impaired, as evidenced by higher levels of lactate and other measures of oxidative stress.
2. http://solvecfs.org/deciphering-post-exertional-malaise/
Extract from the above page:
Current clinical descriptions and case definition criteria of PEM are not currently quantified well-enough to be used in the laboratory setting. As a result, most studies have had to operationally define PEM. This has led to PEM being described and defined in a host of different ways including: ....
Effect of noni and cisplatin on the level of malondialdehyde.
Increased levels of Malondialdehyde (MDA) indicate upsurge in lipid peroxidation which is a consequence of increased free radical generation. It causes profound alterations in the function of the cell membrane and structural organization of DNA leading to mutations. Therefore, it can be stated that lipid peroxidation may possibly be involved in cervical carcinogenesis. On treatment with Noni, CP, and their combination, the level of MDA decreased by 0.76 fold, 0.49 fold, and 0.68 fold respectively in HeLa cells; and by 0.93 fold, 0.67 fold, and 0.79 fold respectively in SiHa cells, as compared to their controls (Figure 1A).
Effect of noni and cisplatin on catalase activity
Catalase is an ubiquitous antioxidant enzyme that is present in most aerobic cells. Catalase is involved in the detoxification of hydrogen peroxide, a reactive oxygen species (ROS), which is a toxic product of both normal aerobic metabolism and pathogenic ROS production. On treatment with Noni, CP, and their combination, Catalase activity was found to be increased by 1.61 folds, 0.54 fold, and 2.35 folds respectively in HeLa cells; and by 0.98 fold, 0.39 fold, and 1.85 folds respectively in SiHa cells, as compared to their controls (Figure 1B).
***** ****
Please note that anti-oxidant properties of noni juice also contribute to the reduction oxidative stress, thus reduced or no PEM and increased energy levels.
I use up to 150 ml of noni juice, 50 to 75 ml two to three time a day based on my body feeling. For me noni juice combined with potent natural multivitamins and protein powders gave good result over a period of time. I could notice improvement in no time.
If anyone tried noni juice please share your experience.
Have fun,
Hari
Original research articles: (both the studies are done by Rakesh Kumar and teams from India)
On Mitochondria: http://www.apocpcontrol.org/paper_file/issue_abs/Volume14_No1/237-242 12.8 Rakesh Kumar Gupta.pdf
On Oxidative stress related: http://www.apocpcontrol.org/paper_file/issue_abs/Volume14_No8/4603-4606 1.19 Rakesh Kumar Gupta.pdf
My earlier related posts: www.cortjohnson.org/forums/threads/the-principle-i-followed-to-restored-my-health.2957/
In my earlier posts I mentioned that Noni Juice helped me to gain energy, but I did not know why. With the interest to help all of you to know why, and encourage you to try noni juice under the supervision of your physician. I searched PubMed database for noni and mitochondria.
Morinda Citrifolia is scientific name for Noni.
Please note the studies are not done for FMS / CFS. But I find relevance to FMS / CFS based on other related information.
Noni and Mitochoandria
Here is the explanation by Dr. Mayhill: http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure
Here is the scientific evidence: Morinda Citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders.
http://www.apocpcontrol.org/paper_file/issue_abs/Volume16_No4/1675 8.14 Caramel Simone [Letter to Editor].pdf
Extract from above link:
QBS tests, by evaluating both parenchymal and microcirculatory parameters, confirm the already well known anti-oxidant properties of Noni fruit and other peculiar properties such as (a) diminishing/normalizìng the tissue acidosis, (b) re-equilibrating the acid-basic balance, (c) ameliorating/normalizing the mitochondrial redox activity as well as the tissue oxygenation, the microcirculatory flow motion and the metabolism as a whole
***** *****
I also found that noni juice reduces oxidative stress. Outcome of oxidative stress for FMS / CFS could be PEM - Post Exertion Malaise.
Oxidative stress may cause PEM:
1. http://solvecfs.org/post-exertional-malaise-cause-and-effect/
Extract from the above page:
....Studies have found that peak oxygen consumption and maximum capacity for oxygen consumption are lower in CFS patients than controls
......Research has also suggested that muscle energy metabolism is impaired, as evidenced by higher levels of lactate and other measures of oxidative stress.
2. http://solvecfs.org/deciphering-post-exertional-malaise/
Extract from the above page:
Current clinical descriptions and case definition criteria of PEM are not currently quantified well-enough to be used in the laboratory setting. As a result, most studies have had to operationally define PEM. This has led to PEM being described and defined in a host of different ways including: ....
- Various biological markers (e.g. complement C4a, cytokines, natural killer cells, NF-кB, oxidative stress, gene expression, etc.)
Effect of noni and cisplatin on the level of malondialdehyde.
Increased levels of Malondialdehyde (MDA) indicate upsurge in lipid peroxidation which is a consequence of increased free radical generation. It causes profound alterations in the function of the cell membrane and structural organization of DNA leading to mutations. Therefore, it can be stated that lipid peroxidation may possibly be involved in cervical carcinogenesis. On treatment with Noni, CP, and their combination, the level of MDA decreased by 0.76 fold, 0.49 fold, and 0.68 fold respectively in HeLa cells; and by 0.93 fold, 0.67 fold, and 0.79 fold respectively in SiHa cells, as compared to their controls (Figure 1A).
Effect of noni and cisplatin on catalase activity
Catalase is an ubiquitous antioxidant enzyme that is present in most aerobic cells. Catalase is involved in the detoxification of hydrogen peroxide, a reactive oxygen species (ROS), which is a toxic product of both normal aerobic metabolism and pathogenic ROS production. On treatment with Noni, CP, and their combination, Catalase activity was found to be increased by 1.61 folds, 0.54 fold, and 2.35 folds respectively in HeLa cells; and by 0.98 fold, 0.39 fold, and 1.85 folds respectively in SiHa cells, as compared to their controls (Figure 1B).
***** ****
Please note that anti-oxidant properties of noni juice also contribute to the reduction oxidative stress, thus reduced or no PEM and increased energy levels.
I use up to 150 ml of noni juice, 50 to 75 ml two to three time a day based on my body feeling. For me noni juice combined with potent natural multivitamins and protein powders gave good result over a period of time. I could notice improvement in no time.
If anyone tried noni juice please share your experience.
Have fun,
Hari
Original research articles: (both the studies are done by Rakesh Kumar and teams from India)
On Mitochondria: http://www.apocpcontrol.org/paper_file/issue_abs/Volume14_No1/237-242 12.8 Rakesh Kumar Gupta.pdf
On Oxidative stress related: http://www.apocpcontrol.org/paper_file/issue_abs/Volume14_No8/4603-4606 1.19 Rakesh Kumar Gupta.pdf
My earlier related posts: www.cortjohnson.org/forums/threads/the-principle-i-followed-to-restored-my-health.2957/
Last edited:
