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  1. P

    Who doesn't benefit from acetylcholine supplements?

    Ha, I'd hardly say that! All I can attest to is that blocking the acetylcholine has altered the patterns of my peripheral neuropathy -- so I think the researchers are probably on to something if they can figure out how to "weaponize" their findings effectively. So far I've seen no significant...
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    Who doesn't benefit from acetylcholine supplements?

    Very interesting, @Issie. I too have been enjoying the effects of pregnenolone every morning, along with galantamine, which I think has a lot of similar qualities to huperzine -- and no longer requires a prescription either. Seems that "balancing" acetylcholine is more productive for me than...
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    Who doesn't benefit from acetylcholine supplements?

    Thanks for the links. I had no idea nerve warfare was cholinergic! Interesting that clonidine is one of the preferred treatments, since it's become one of my most reliable sleep aids. Well, I can say with high-level confidence that some permanent changes have taken place (or, at least...
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    Possible Mechanism Identified for 'Chronic Fatigue Syndrome'

    Yes! This is such an important point, I think. And there are countless analogous questions that should be formulated the same way. It's so easy to get misdirected with wild goose chases about reactions to all sorts of specific substances, receptors, transmitters, etc -- whereas the core...
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    Who doesn't benefit from acetylcholine supplements?

    I've been meaning to give a final update on my little experiment, but wanted to give enough time to gauge the permanency of the changes. For me the results have been very interesting, mainly because they've been so conclusive. What I can say conclusively is that some of my peripheral nerves...
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    What's this about 23andMe?

    Thanks both, good info. So it sounds like the new FDA approval won't change the raw data necessarily, but mainly how 23andMe is allowed to interpret/market it? What I still don't have a real grasp of is the scope of the raw data from a 23andMe purchase. I understand @Remy saying it's more...
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    What's this about 23andMe?

    So now the FDA is allowing 23andMe to sell disease-oriented genetics testing. I've faced a long-term gumption trap when it comes to ponying up the money for 23andMe -- since every time I've looked into it the disease-oriented genetics seems so limited. Do folks here still believe it's...
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    My modafinil experience, Provigil, drug allergy

    I can't take it either since it started making my mouth and tongue swell up. (Was ordered to urgent care where I spent a half day -- but that's another story.) I've tried many stims, having the most success with (the atypical) buproprion, but after three or four months of daily use it suddenly...
  9. P

    Who doesn't benefit from acetylcholine supplements?

    Baclofen helps me sleep, but I notice in my CPAP data more breathing disturbances with it. Odd. Flexeril never made much of an impression; interesting to learn it's anticholinergic. Recently I've been having interesting -- mostly positive -- results from low-dose galantamine, which is said to...
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    So....Trump cuts 20% from NIH funding...

    It's necessary in order to build a Great Wall to keep wildlings out.
  11. P

    Chronic Fatigue X Files

    Such rich lives and experiences around here! Romanticizing past generations and cultures is always risky, but we certainly seem to have lost a lot while we've made many material gains. In certain respects our current age will be remembered as a dark age, I believe, since we have elevated...
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    Powder City Close-Out Sale

    Powder City is closing shop. Too bad, they've always treated me well. Check out their closing sale quick. Items are going fast (some ran out before I paid for my cart), but there's still plenty of powder and capsules like baicalin, rhodeola, pterostilbene, magnesium, IP6, curcumin, glutamine...
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    Chronic Fatigue X Files

    Some of the experiences you both are describing are also common to many descriptions of hallucinogenic experimentation. Researchers are again getting serious about looking into hallucinogens for pain relief, grief, and -- who knows? -- maybe disease reversal. (Such research was put on hold for...
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    Could Donald Trump Be Good For Chronic Fatigue Syndrome and Fibromyalgia?

    That is some awful shit. Completely doubling down on their opposition to Obamacare's preexisting condition fix, which is very popular. Hopefully the GOP is purposely designing something to fail, so they can tell their dumb-ass constituents they tried to blow the whole thing up but Obama's shadow...
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    Restless leg feeling all over.

    I look forward to hearing more about your visit with Hesch. You seem to be on to something. I have had some improvement since I started using a pressure-point pillow that kind of elongates the neck and puts the head in a very neutral position. Re cannabis, I only vape, and it seems to have no...
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    Chronic Fatigue X Files

    What a chilling story from Hillenbrand! From your readings and experiences are you coming to any conclusions about these complexities and sensitivities? E.g., are they a manifestation of illness, or a predisposition?
  17. P

    Restless leg feeling all over.

    That's intriguing, as I've had neck issues for decades (including the fact that it sounds and feels like there's gravel in there every time I turn my head. I've been meaning to try an acupuncturist. @Ladyliegh -- You've been trying all the right things, IMO. I could never tolerate Flexeril, or...
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    Could Donald Trump Be Good For Chronic Fatigue Syndrome and Fibromyalgia?

    It would seem Ayn Rand was against the whole concept of insurance -- judging by her sycophant Paul Ryan's latest comments about it not being fair that healthy people have to pay for sick people's care. That's precisely what insurance pools are all about!!
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    Could Donald Trump Be Good For Chronic Fatigue Syndrome and Fibromyalgia?

    Which is one of the problems with having a president who will say anything with no regard to the truth or facts. People then are liable to hear only what they want to hear. This is why it's so hard to limit this thread to a rational discussion of Trump "policies." The word is absolutely...
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    Provigil (Modafinil)

    I had been thinking half-doses of Nuvigil (similar to Provigil) was helpful on particularly bad days. But I gradually developed a pronounced reaction -- swollen, sore mouth and tongue. My doc made me spend an entire evening in an emergency room out of fear of Stevens-Johnson. Now, I can't even...

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