Did you recover from adrenal insufficiency? I'm currently trying DHEA - another anti-inflammatory which helps adrenal insufficiency. Why did you stop - did you have a bad response?I am familiar with dex...I took a low dose of it when I was diagnosed with adrenal insufficiency, but I've since stopped it.
It does not activate nrf2...if anything, it inhibits it.
PubMed: "Anti-inflammatory efficacy of dexamethasone and Nrf2 activators in the CNS using brain slices as a model of acute injury." Maybe someone else can read it and decipher the article. it's anti-inflammatory - but the article was difficult to comprehend. I get very weary trying to sort it all out myself - which is why I came here. Sometimes supplements can help to a degree - other times one may need a heavy-hitter pharmaceutical. It would be interesting to know if anyone has found a pharmaceutical to up-regulate Nrf2. There is a neurologist - can't recall his name, who recommends Nrf2 activators.