Brain Fog is likely mast cell and glial inflammation.

Cort

Founder of Health Rising and Phoenix Rising
Staff member
To: Who me? I hope you understand - there was no offense intended. You sound like a caring person. I am in a race to find answers for my health issues - I'm sure we all are. Had I known you would have been irritated at the medical worker's remark, I would not have repeated it. I had no way of knowing. I try to pass on information that I learn, in the hope that it will help someone else.

I believe it was you who suggested the Memantine and Ibidulast - I ordered it. I received the Ibidilast and started it, and am tolerating it well. Since this is a brain fog thread, I came across information again at how inflammation is at the root of it all - then it points to digestion again. But my brain is so filled with medical journals - I have not found conclusive answers.

I came across documentation that SOD - Superoxide Dismutase - works to help brain inflammatory conditions. The problem is, SOD is not absorbed readily, as it is broken down in the digestive system. You can try the GliSODin - which is SOD bound to a wheat protein, or liposomal SOD. I didn't want to take wheat, so i've been combing the internet and can't find where to buy it.

Cort - you are probably already 10 steps ahead of me on this - but did you ever do an article on SOD ? Theoretically, since it controls inflammation, it could help brain fog/ other issues. Maybe you/ someone else found a good place to buy it.
Actually I'm ten steps behind (lol). I've never done a blog on SOD.

By the way when someone does @Cort - where is that supposed to show up? I never seem to get the alert - is it in the alert section? (which I never look at (lol))
 

cherubim

Well-Known Member
I guess none of us know what another person knows:) You may know all of the following, but didn't do a blog yet. SOD is found low in some inflammatory disorders and is instrumental in fighting ROS. I couldn't find any good ways to raise SOD & Catalase besides using the SOD with gliadin (wheat protein). I found one expensive cream - so I ended up trying the SOD with gliadin. That defeats my trying to remain wheat & gluten-free, but it comes down to what you can afford.

Don't know if you did a blog on Nrf2 activators either. They are what instruct the body to release it's own antioxidants. There are natural things, like sulforaphane that work. From what I read, oxidative stress is behind many disorders. The pharmaceuticals apparently pack more punch, but don't know if they're on the market yet - unless someone has found them overseas. I'd love to try one.
 

Veet

Well-Known Member
By the way when someone does @Cort - where is that supposed to show up? I never seem to get the alert - is it in the alert section? (which I never look at (lol))
Hi Cort. Yes, the red flag at top right of any forum page. :banhappy::)
 
A poster on Reddit earlier talked about how a steroid Prednisone (for a breathing problem) had massively cleared up his brain fog: https://www.reddit.com/r/Nootropics/comments/53kgsd/could_inflammation_be_my_cause_of_brain_fog/

Steroids definitely don't seem like a good recommendation (long term), and this guy had a lot of general inflammation in joint issues, etc, so I don't know if clearing that up was the main factor there...?

Also mentions NSAIDs - a high dose of ibuprofen (2 grams) clearing his mind. So aspirin, ibuprofen and naproxen (or Paracetamol) helped anyone?

A comment there linked to Lostfalco's original article, as it happens, so I linked to this thread. ;-)


On a separate note, what about glutathione, e.g. as an IV therapy? I was reminded of this facebook update from the Paleo Mom (Sarah Balantyne) and how wonderfully brain soothing this sounded:
[...] that gluathione tends to be low in many autoimmune diseases [...]

Unfortunately, most glutathione supplements don't enter the body intact since they are very easily digested.[...]

I feel good in a way that's difficult to describe. It's not particularly relaxed, or particularly energetic. [...] I guess the best description is that I feel clear and focused in a way I haven't for a while.
Cropper2016-09-20-18-46-29-7219894.jpg
Anyone else had good brain times with intravenous nutrition? She links here. I know old Ray Kurzweil has regular IV nutrients too, as part of living forever, but imagine his might have unicorn tears in too, or something very expensive...
 

Sue Stevenson

Active Member
I look back fondly on the time I was on prednisone. I definitely experienced a brain lightening with that. I understand how it can be addictive
 

Sue Stevenson

Active Member
Re ordering from Mimaki pharmacy

Has anyone had any probs? I'm trying to enter my credit card details and it keeps telling me i have entered invalid characters in the name section when I haven't .

??
 

Remy

Administrator
Re ordering from Mimaki pharmacy

Has anyone had any probs? I'm trying to enter my credit card details and it keeps telling me i have entered invalid characters in the name section when I haven't .

??
That happened to me too once. I think i tried a different card the next day and it processed.

They are responsive to email, reasonably fast (within 1-2 days). Maybe shoot them an email and see if they can tell you what the problem is?
 

Sue Stevenson

Active Member
Thanks, all. I used my partner's card and now the ibudilast sits in my PO box like a (kinda boring rrally) early Christmas present.

@Remy did you have any teething issues starting up galantamine? I took my first one this afternoon and like @rebar slept heavily for several hours. I'm willing to give it another try on another day where I wasn't wiped to begin with but do wonder if this reaction means I'll always react like this.

Or maybe i is one of the fillers - silicon dioxide or microcrystalline cellulose.
 
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Remy

Administrator
Thanks, all. I used my partner's card and now the ibudilast sits in my PO box like a (kinda boring rrally) early Christmas present.

@Remy did you have any teething issues starting up galantamine? I took my first one this afternoon and like @rebar slept heavily for several hours. I'm willing to give it another try on another day where I wasn't wiped to begin with but do wonder if this reaction means I'll always react like this.

Or maybe i is one of the fillers - silicon dioxide or microcrystalline cellulose.
I didn't but I'm not particularly sensitive to things so I might not be the best one to ask.

Maybe try a smaller amount too?
 

Sue Stevenson

Active Member
Yes, i woke up thinking my usual rush-in-at-full-dose strategy may need tweaking on this one. Takes a long time to unlearn that approach ☺ Thanks, @Remy
 

Hiver

Member
Have any of you early birds started to notice any effect from Ibudilast yet?

How long is the half-time of Ibudilast?

As Ibudilast supresses Cytokyines: would it affect blood test results?

(I apologize for my need to be short/direct.)
 
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rebar

Active Member
I'm curious too, as I didn't get anything out of it after a couple of months. Maybe I didn't give it a long enough trial, but now Im cutting out most everything, it seems nothing I ever do helps. Actually the less I do the better I feel.
 

Remy

Administrator
Have any of you early birds started to notice any effect from Ibudilast yet?
I am still feeling pretty not bad (knock on wood!) but I haven't stopped the ibudilast to try to tell if it is playing a major role or not.

I'm willing to give it a longish term trial based on the evidence and Dr Younger's interest in it though. I would think it could take some time to reverse kindling in the glial cells, maybe.

I'm still taking 10 mg twice a day.
 

cherubim

Well-Known Member
Hi - I bought Ibudilast from the recommendation of someone here. It works good - so I went to reorder and Mimaki Pharmacy doesn't have it. Does anyone know where to find it?

thx!
 

Remy

Administrator
Hi - I bought Ibudilast from the recommendation of someone here. It works good - so I went to reorder and Mimaki Pharmacy doesn't have it. Does anyone know where to find it?

thx!
I think that the cheaper Pinatos may have been discontinued but the more expensive Ketas is still available.
 

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