The microglia in the brain and spinal cord are getting more and more interest in Fibromyalgia and Chronic Fatigue Syndrome. Given their roles in producing both neuropathic pain and neuroinflammation it’s hard to believe they’re not involved in producing the pain and fatigue in FM and ME/CFS.
Neuropathic pain or nerve pain is common in Fibromyalgia and ME/CFS. A notoriously tough nut to crack treatment-wise, neuropathic pain may be so hard to beat because the drugs used try to catch the fox after he’s gotten out of the henhouse; i.e., they attempt to block excess nerve activity but don’t get at the inflammatory factors – very possibly produced by the microglia – that cause the nerves to go bonkers in the first place.
Now a study suggests that cannabanoids reduce neuropathic pain by calming down the microglia. It found that drugs regulating canabannoid activity in the microglia early in the course of neuropathic pain can both stop the microglial growth and the development of neuropathic pain that associated with it.
This suggested that taking Nabilone, a synthetic cannabanoid, could both help prevent the development of neuropathic pain and reduce it once it occurs. One would assume the same is true for medical marijuana. Please share your experiences with medical marijuana or Nabilone below.
- Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain Cory C Toth1*, Nicole M Jedrzejewski1, Connie L Ellis1, William H Frey II2. Toth et al. Molecular Pain 2010, 6:16