Small Fiber Neuropathy (SFN) Fibromyalgia and ME/CFS Resource Page

small fiber neuropathy fibromyalgia

The first problem discovered in FM was fewer nerve fibers than usual in the skin. (The dark lines are the nerve fibers). (Photomicrograph courtesy of Therapath Laboratory (NY, NY))

Small fiber neuropathy refers to the loss and/or degradation of small nerve fibers in the skin and eyes (and perhaps elsewhere) of approximately 40% of people with fibromyalgia and/0r chronic fatigue syndrome (ME/CFS) as well. These nerve fibers can transmit sensory and autonomic nervous system signals to the brain.

Studies indicate that the presence of SFN exacerbates the symptoms of fibromyalgia. While the role SFN plays in fibromyalgia, ME/CFS, postural orthostatic tachycardia syndrome (POTS), and now long COVID is unclear, it could help explain the pain, central nervous system sensitization, and even autonomic nervous system problems found in these diseases.





Fibromyalgia (FM)

Chronic Fatigue Syndrome (ME/CFS)



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