The first problem discovered in FM was fewer nerve fibers than usual in the skin. (The dark lines are the nerve fibers). (Photomicrograph courtesy of Therapath Laboratory (NY, NY))
Small fiber neuropathy refers to the loss of small nerve fibers in the skin and eyes (and perhaps elsewhere) of approximately 45% of people with fibromyalgia and probably many people with chronic fatigue syndrome (ME/CFS) as well. These nerve fibers can transmit sensory and autonomic nervous system signals to the brain.
SFN could help explain the pain, central nervous system sensitization and even autonomic nervous system problems in FM.
Resources
Diagnosis
- Diagnosing Small Fiber Neuropathy
- An Easy Way to Tell if You Have Small-Fiber Neuropathy? The Fibromyalgia Symptom Study (2017)
- Small Fiber Neuropathy Symptom Screening List
- Diagnosing Fibromyalgia The Small Nerve Fiber Way
Treatment
Research
Chronic Fatigue Syndrome (ME/CFS)
- Damaged Small Nerve Fibers May be Causing Energy Problems in Chronic Fatigue Syndrome (ME/CFS) (2021)
- Is Fibromyalgia and Chronic Fatigue Syndrome Actually Small Fiber Polyneuropathy? (2020)
Fibromyalgia (FM)
- Is Fibromyalgia and Chronic Fatigue Syndrome Actually Small Fiber Polyneuropathy? (2020)
- How Nucynta – an Opioid Drug – Told Us Something About the Small Fiber Neuropathy in Fibromyalgia (2020)
- More is Not Better: Increased Small Nerve Fiber Problems in Fibromyalgia Spell Trouble (2019)
- Is the Brain Causing the Small Fiber Neuropathy in Fibromyalgia (and ME/CFS?) (2019)
- 2018 Dysautonomia International Conference I: Small Fiber Neuropathy, POTS, MCAS and Vagus Nerve Stimulation (2018)
- More Than Skin-Deep: The Small Nerve Fiber Problems in Fibromyalgia – A Review
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Small Nerve Fiber Study Finds Different Kinds of Fibromyalgia Exist (2016)
- Optic Nerve Thinning Suggests Fibromyalgia is “Neurodegenerative” Disease (2016)
- Eye-Opening Finding: Small Fiber Neuropathy Found in Fibromyalgia Patient’s Eyes
- Fibromyalgia, Small Fiber Neuropathy and Eye-Opening Developments in Pain Research: An FM and Pain Researcher Talks
- Small Fiber Neuropathy Fibromyalgia Studies Mount But Does SFN Cause Pain in FM?
- Small Fiber Nerve Study Suggests New Era in Fibromyalgia (and Perhaps Chronic Fatigue Syndrome) Could Be At Hand
- Damaged Neuroprotective Process Spells Pain for Fibromyalgia – Suggests Small Fiber Neuropathy is Present
- Small Nerve Fiber Neuropathy Commonly Found in Fibromyalgia (and Linked to Central Sensitization) (2014)
- Are Both Small AND Large Fiber Neuropathy Present in Fibromyalgia? (2014)
- The ‘Body’ is Back in Fibromyalgia: Small Nerve Fiber Damage Suggests The Pain Begins There (2014)
- Small Fiber Neuropathy Fibromyalgia Study Raises Questions
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Hands Up! A Key to the Fatigue, Sleep and Pain in Fibromyalgia Found? (2013)
