Simmaron Spinal Fluid Study Finds More “Immune Exhaustion” in ME/CFS

by Cort Johnson | Apr 3, 2015 | Brain, Cerebral Spinal Fluid, Cytokines, Homepage, Immune | 8 comments

In the most comprehensive study of immune factors in the cerebral spinal fluid ever done in ME/CFS, Mady Hornig and Ian Lipkin reported finding dramatic differences in ME/CFS patients.

The results of the Simmaron Research Foundation /Chronic Fatigue Initiative study suggested that an extensive immune exhaustion – caused by infection or another process – had occurred in the longer duration ME/CFS patients.

The results mirrored the findings of their recent large blood cytokine study and could help explain the cognitive problems found.

Learn more in the Simmaron Research Foundation sponsored blog

▪ Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome

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8 Comments

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Matthias on April 3, 2015 at 4:53 pm

Wow, this sounds like a landmark study. Great and well done!
Now, verification and treatment research please.
Reply
- Cort Johnson on April 3, 2015 at 5:03 pm
  
  Indeed….
  Reply
  - sunie on June 22, 2019 at 11:13 pm
    
    Cort,
    
    by these comprehensive csf studies are Borrelia and nematodes with Borrelia insde of them completely ruled out by their tests?
    
    or has this already been ruled out in previous years?
    
    Thank you for wading thru rheems of info.
    
    Had come across info from 2016 and thought since so many symptoms shared between MS and ME/CFS……
    
    Re: Dr. Alan B. MacDonald findings
    
    https://www.healthrising.org/forums/threads/is-lyme-behind-chronic-brain-disease.4364/
    Reply
Matt on April 4, 2015 at 9:22 pm

……this and Julia Newtons paper. Landmark and amazing papers! Hope further work follows.
Reply
Matthias on April 4, 2015 at 10:32 pm

Would be interesting to read the whole paper.
Which cytokines were lower?
IL10?
Reply
Matthias on April 4, 2015 at 10:37 pm

Do you know a Japanese researcher found issues with IL1 signalling in the early / mid 1990s in CFS?
And that he had success in treating with Sizofiran?
Reply
Rachael on April 5, 2015 at 8:55 am

“Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the central nervous system, and a shift toward an allergic or T helper type-2 pattern associated with autoimmunity.”
************************

A predominance of a Th2-type response is consistent with pathologies, such as autoimmunity and also atopy, a genetic predisposition toward the development of hypersensitivity reactions against common environmental antigens.
Reply
Matthias on April 5, 2015 at 4:00 pm

It costs to see the article. Cort can you advise which cytokines were downregulated?
Cheers
Reply