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(Thanks to Dr. Courtney Craig for allowing Health Rising to publish her blog on the possible benefits of ketogenic diets for people with chronic fatigue syndrome and fibromyalgia. Please note the title was changed and the links at the end of the blog were added by Health Rising.)

Being a ME/CFS patient in remission is a deeply humbling experience. Even though I think I have the illness under my thumb, there’s no doubt that something could happen to quickly turn the tables the other way.

I was reminded of this back in January.

First came the flu, with laryngitis so severe I could no longer teach my classes (or record podcast episodes!). Then came pneumonia. After 4 weeks came a secondary cold, then another. Next a rib strain so severe from coughing, it sent me to the ER because I was certain I had a fracture.

My immune system was hurting, and musculoskeletal injuries frequently set me into relapse because of the cytokine storm. By late February I was getting better. But my crushing fatigue was back, my sleep was disturbed, my muscles were weak. I was having trouble getting around on the subway.

Unfortunately, I was feeling like a ME/CFS patient again.

This relapse was a doozy! Despite throwing everything I knew at it, I was losing the game against relapse. Even intermittent fasting wasn’t doing the job.

I needed a serious immune and mitochondrial reset. So I shifted my usual paleo-diet around, and astonishingly I bounced back very quickly. I no longer felt like a ME/CFS patient. The illness was back under my thumb.

How’d I do it? I started consuming about 80% of my calories from healthy fats. Sounds crazy right? This is something I do periodically when the fatigue rears its ugly head. It’s also advocated by doctors like Dr. Terry Wahls for MS patients, Dr. Andreas Eenfeldt for weight loss, and Dr. Thomas Seyfried for cancer.

I flipped a switch on my metabolism. I stopped relying so much on glucose for metabolism, and instead encouraged my liver to break down those dietary fats into ketones—a much “cleaner” energy source.

The biohacker in me closely monitored this process with some inexpensive tools. Ketostix’s measure ketones in urine and a glucometer measures blood sugar and blood ketones.

Ketogenic diets have profound effects on the mitochondria, the brain, and immune cells, so why shouldn’t they be considered for ME/CFS and Fibro?

Periods of fasting are an excellent way to maintain ketosis but more intense fasts may be required in some people to achieve benefit. It’s a great way to do some cellular spring cleaning.

Ketogenic Diets

ketosis

You probably haven’t heard about the ketogenic diet. It hasn’t garnered the media attention like Atkin’s, South Beach, or Paleo. The ketogenic diet, however, has been around since the 1920’s, and is one those in the ME/CFS and Fibro community might want to get to know.

First popularized in the 1920s as an effective treatment for intractable epileptic seizures, the diet is still used today for epileptics that fail medications. It has also been widely studied as an adjuvant in cancer and other neurological disorders such as Parkinson’s, ALS, and Alzheimer’s. A Cochrane meta-analysis highlighted the safety and effectiveness of this diet for controlling seizures (1).

Implementing a ketogenic diet is quite different than other big name diet plans. In order to become “keto-adapted,” the dieter must flip a switch on their metabolism. Instead of burning carbohydrate (glucose) for fuel, the cells must switch over to burning fats in the form of ketones. The downside of burning carbohydrate as fuel, is production of cellular stress and free radicals. Ketones provide a “cleaner” energy for cells and are less damaging to cell membranes. This could be compared to a car burning diesel (carbohydrate) versus a car burning unleaded gasoline (ketones).

This is not to say glucose is completely absent in someone who is keto-adapted. Dietary protein can also be a source of glucose for vital organs that require constant supply, such as the brain. Too much protein however, can cause blood sugar surges that stimulate insulin and “undo” the keto-adapted state.

A ketogenic diet can be initiated with a 12-72 hour fast. Then the diet is maintained by consuming 75-90% of calories as fat, with the remainder coming from moderate amounts of protein and very little carbohydrate.

The ketogenic diet is one that should be considered when dealing with ME/CFS, and perhaps even Fibromyalgia. A body of research in animals and humans have highlighted some of the mechanisms by which dietary ketones promote cellular health.

Here I highlight 3 compelling reasons why the ME/CFS and Fibro community should get to know ketosis.

Mitochondria

By their very nature as ATP-churning, energy machines, mitochondria produce an enormous quantity of free radicals. These radicals must be “quenched” by antioxidants to reduce the damage to the delicate organelle’s scaffolding. Glutathione, selenium, coQ10, and others play a key role in combating the free radical onslaught.

Mitochondrial dysfunction is widely recognized as a contributor to ME/CFS and Fibromyalgia symptoms. Indeed, many studies have determined that patients have depleted antioxidants, leaving mitochondria particularly vulnerable (2,3).

Ketogenic diets have been found to reduce free radical damage and thereby improve mitochondrial function. Also, ketogenic diets have been found to increase glutathione synthesis–the most important antioxidant for the mitochondria (5). In a recent study, fibroblasts from fibromyalgia patients were found to have decreased mitochondria per cell. When patients were given the metabolic drug metformin and prescribed caloric restriction (a means to achieve ketosis) the fibroblasts showed a more resilient response to free radical damage (4).

cell fuel

Immune

New studies are emerging demonstrating the role of ketosis in regulating the immune system. In animal models, a 72-hour fast that increases blood ketones, stimulates hematopoetic stem cells. These are cells that will differentiate into various types of white blood cells (6).

A blockbuster ME/CFS study is now underway studying the effects of the B-cell depleting drug Rituximab (7). This cancer drug may provide relief for a subset of patients through similar mechanisms as ketosis—out with the dysfunctional immune cells, in with new. Rituximab has also been studied in autoimmune diseases such as RA. Fasting studies in RA patients demonstrated reduced joint pain and inflammation, which suggests a similar mechanism (10).

Promoting a ketogenic state during the use of Rituximab may make the drug better tolerated and promote a more robust immune response. Ketogenic diets, achieved through fasting, are being studied as a cancer adjuvant to lessen the toxic effects of traditional chemotherapy in various cancers (10).

Neuroinflammation

The topic of neuroinflammation in ME/CFS is starting to gain traction as new research emerges. A Japanese group detected neuroinflammation on PET imaging (8). Newcomer Jarred Younger detected high levels of the pro-inflammatory molecule leptin in a cohort of patients (9). The effects of leptin occur in the brain and may promote “sickness behavior,” or more commonly, malaise. Animal models of ME/CFS have also demonstrated neuroinflammation driven by inflammatory antiviral molecules, like IFNγ. Increased IFNγ has been a consistent, yet non-specific, finding among ME/CFS research (2).

Ketones have demonstrated their ability to down regulate IFNγ and reduce leptin (10). Other pro-inflammatory cytokines have been shown to reduce in a ketotic state; IL-6 and IL-1β. Finally, ketogenic diets increase the production of BDNF in the brain, which stimulates neuronal stem cells and repairs damaged neuronal connections–a potential perpetrator of the dreaded brain fog (10).

Fasting: Molecular Mechanisms and Clinical Applications Longo & Mattson (2014)

Summary Of Ketogenic Diet Effects

  • Increases glutathione production
  • Increases BDNF gene expression
  • Increases mitochondria concentration
  • Stimulates hematopoetic stem cells
  • Reduces inflammatory molecules (leptin, IFNγ, IL-6, IL-1β)
  • Reduces oxidative stress at the mitochondria

____________________________

Dr. Courtney Craig D.C. was first diagnosed with CFS as a teen in 1998, and recovered in 2010 utilizing both conventional and integrative medicine.

Trained as a doctor of chiropractic and nutritionist, she now provides nutrition consulting and blogs about what she’s learned at www.drCourtneyCraig.com/blog.

Dr. Craig offers online nutrition consultations to patients worldwide looking to change their diet. Get the details in a free 15-minute call.

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Health Rising

  • Check out resources on ketogenic diets including recipes in the resource section of the Health Rising Forums
  • If you’ve tried a ketogenic diet please tell us how it went in our review section.

Trending on the Health Rising Forums:

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1  Levy RG, Cooper PN, Giri P. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2012 Mar 14;3:CD001903. http://www.ncbi.nlm.nih.gov/pubmed/22419282

2  Maes, M, et al. Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Sci Monit. 2011 Apr;17(4):SC11-5.http://www.ncbi.nlm.nih.gov/pubmed/21455120

3  Cordero MD, et al. Oxidative stress and mitochondrial dysfunction in fibromyalgia. Neuro Endocrinol Lett. 2010;31(2):169-73. http://www.ncbi.nlm.nih.gov/pubmed/20424583

4  Alcocer-Gómez E, et al. Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients. Biochim Biophys Acta. 2015 Mar 14. pii: S0925-4439(15)00069-1. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25779083

5  Swann JW. How Does the Ketogenic Diet Work? Epilepsy Curr. 2004 Jan;4(1):20-21.http://www.ncbi.nlm.nih.gov/pubmed/15346140

6  Cheng CW, et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 5;14(6):810-23.http://www.ncbi.nlm.nih.gov/pubmed/24905167

7  Fluge Ø, et al. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS One. 2011;6(10):e26358.http://www.ncbi.nlm.nih.gov/pubmed/22039471

8  Nakatomi Y, et al. Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study. J Nucl Med. 2014 Mar 24;55(6):945-950.http://www.ncbi.nlm.nih.gov/pubmed/24665088

9  Stringer EA, et al. Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology. J Transl Med. 2013 Apr 9;11:93.http://www.ncbi.nlm.nih.gov/pubmed/23570606

10  Longo VD & Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014 Feb 4;19(2):181-92. http://www.ncbi.nlm.nih.gov/pubmed/24440038

 

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