Blogs

General

• Longtime ME/CFS Drug Ampligen Gets Its Shot with Long COVID

• Making the Case for Ampligen in Chronic Fatigue Syndrome (ME/CFS)
• Dr. Peterson Talks on Ampligen, Autoimmunity, Pathogens and Simmaron – Dr. Peterson on Ampligen plus three patient stories
• The Ampligen Chronicles – in entertaining, at times side-splitting  fashion, Kelvin Lord tracks his progress on Ampligen from a highly disabled person with chronic fatigue syndrome to…..
• Dr. Lapp – A Pioneer and Patriarch: An Interview by Kelvin Lord – Ampligen recipient Kelvin Lord talks with a doctor with intimate knowledge of Ampligen.
• Ampligen: Twisted History – the story of Ampligen and Hemispherx is a long and tangled one
• Ampligen Co-Inventor / Head of Hemispherx Biopharma Fired: Implications for ME/CFS Drug Unclear

Patient Stories

• Anita Patton – What Ampligen Means to Me
• Anita Patton’s Recovery Story
• The New Ampligen Diaries –  Kelvin Lord’s entertaining reviews of his experience of a year on Ampligen
• Four Patient Stories – presented 1998 at AACFS Conference
• Mary Schweitzer’s 1999 Testimony

FDA and Drug Approval Process

• Ampligen Takes Big Step Forward – Becomes First Drug Approved Anywhere For Chronic Fatigue Syndrome (Aug 2016)
• New Hemispherx President Says Getting Ampligen Approval Top Priority – (June 2016)
• Clinicians and Biomedical Experts Request Major Ampligen Review at FDA
• Patient launches hunger strike in support of Ampligen Approval (Feb 2013) / Hunger Strike Hits the News (Feb 2013)
• FDA Denial of Ampligen Exposes Out of Touch Agency; Hemispherx to Appeal
• FDA Advisory Committee Meeting Pt 1: Dueling Presentations Set Stage for Critical Vote (Jan 2013)
• FDA Advisory Meeting Pt II: The Vote and Aftermath (Jan 2013)
• Harsh FDA Report…Good Committee…Which Way Ampligen (Dec 20th 2012)
• High Noon for Ampligen – FDA Advisory Meeting is Upon Us (Dec. 2012)
• Ampligen on the Clock: Hemispherx’s ‘Complete Response’ Means Ball is in FDA’s Court Now – Hemispherx’s quick response means Ampligens fate will be known by February, 2013.
• Major Move From FDA Puts Ampligen Back on Track (July 2012) –  the FDA relaxes its requirement for more expensive studies and agrees to review the drug using clearing the way for a decision within 9 months
• Ampligen Study Sparks Hope for FDA Approval of First Drug for CFS (March 2012)  – Hemispherx newest study (using old data) showed Ampligen is safe and effective, relative to other drugs, in increasing endurance.
• Rintatolimod (aka Ampligen) on Trial – CFIDS Association covers the 2012 PLoS One study

Website – Overviews and More

• Ampligen – An overview…what it does….what ME/CFS physicians think of it….past studies…cost…the works!
• Ampligen: Effectiveness – we take a close look at just how effective Ampligen is in CFS

Other Sites

• Hemispherx BioPharma Website – Hemispherx Biopharma is the company that produces Ampligen (Rintatolimod)
• Hemispherx and Chronix present data on diagnostic test at IACFS/ME Conference in Ottawa (Oct, 2011)
• Hemispherx files joint patent with Chronix to produce diagnostic test for chronic fatigue syndrome (March, 2011)
• Ampligen and CFS – Links to Ampligen News to 1998

Studies

• A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. Strayer DR, Carter WA, Stouch BC, Stevens SR, Bateman L, Cimoch PJ, Lapp CW, Peterson DL; Chronic Fatigue Syndrome AMP-516 Study Group, Mitchell WM.PLoS One. 2012;7(3):e31334. Epub 2012 Mar 14.
• Clin Infect Dis. 1994 Jan;18 Suppl 1:S88-95. A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), inchronic fatigue syndrome
• In Vivo. 1994 Jul-Aug;8(4):599-604. Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome
• Ann N Y Acad Sci. 1993 Jun 23;685:756-7. RNA drug therapy acting via the 2-5A synthetase/RNase L pathway. Suhadolnik RJ, Reichenbach NL, Hitzges PM, Ablashi DV, Strayer DR, Carter WA.