LDN is one of the few things that I can say to people that the odds are pretty good that …(it) can reduce your pain. Dr. Ginevra Liptan – Fibromyalgia specialist
Low Dose Naltrexone (LDN) …
Could a low cost, easily available drug that most doctors don’t know about help with your pain or other symptoms? It just might.
Low dose naltrexone (LDN) seems, at first glance, like a strange drug for people with chronic fatigue syndrome (ME/CFS) or fibromyalgia. Usually used in high doses to combat alcoholism and narcotics withdrawal, naltrexone blocks the opioid/endorphin receptors in the brain.
Blocking the receptors that activate the pain-killing opioid pathways or the good feeling producing endorphin pathways wouldn’t seem to be a good thing given that some studies suggest these substances are already low in chronic pain disorders like fibromyalgia and chronic fatigue syndrome (ME/CFS),
Feeling Good Again?
Low-dose naltrexone (LDN), however, works differently than naltrexone. LDN appears to prompt the opioid and endorphin systems to respond with vigor – and produce more “feel-good” substances.
LDN”s blockage of the endorphin and opioid receptors in the brain appears to trick the brain in a kind of rebound effect, to produce more of them. The 4-6 hours or so the drug remains in one’s system is sufficient to boost the levels of endogenous opioids (those naturally found in the brain) for 18-24 hours. Given that endorphins are known as ‘natural pain relievers’ having more endorphins floating around might be a very good thing for people with FM and ME/CFS.
LDN also appears to be able to regulate the activity of immune cells in the central nervous system called microglial cells. When these cells get turned on they produce pro-inflammatory cytokines, reactive oxygen species (free radicals), and nitric oxide – all of which are capable of tweaking the nerves to produce more pain, fatigue, and other symptoms.
Microglial cells appear to play a key role in producing the ‘sickness response’ responsible for the fatigue, fluey feelings, pain, etc. that we associate with colds and diseases like chronic fatigue syndrome (ME/CFS) and fibromyalgia. LDN’s ability to block a key receptor (TLR 4) on microglial cells appears to inhibit them from becoming activated. Recent studies suggesting that neuroinflammation is present in these diseases have put a new spotlight on these cells.
To sum up…
LDN Might Be Effective in Chronic Fatigue Syndrome and/or Fibromyalgia Because…
LDN’s ability to tamp down the activity of microglial cells in the brain could reduce the levels of the pro-inflammatory cytokines that may be producing pain, fatigue, and other symptoms n ME/CFS and FM. LDN may also increase levels of the natural “feel-good” substances such as endogenous opioids and endorphin that have become depleted in these diseases.
- Check out a fascinating video from the Stanford University Medical Center on Fibromyalgia which includes LDN
Fibromyalgia and ME/CFS Low Dose Naltrexone (LDN) Studies
LDN has not been well-studied in either disease but two small fibromyalgia studies led by Jarred Younger suggest LDN may be able to help some people with fibromyalgia. A 2009 single-blind crossover study found that LDN significantly reduced pain, fatigue, and stress levels.
Once patients were off the drug, their symptom levels quickly returned. Intriguingly, a measure of inflammation called erythrocyte sedimentation level (ESR) predicted 80% of the responses. The fact that higher initial ESRs were associated with greater reductions in symptom severity suggests that FM patients with more inflammation might benefit the most from LDN. In other words, the more symptoms you have – the better you might benefit.
A larger placebo-controlled, double-blinded, crossover study (dose 4.5 mg/day) produced similar results: reduced pain, improved mood, and increased general satisfaction with life. LDN was not a miracle drug – FM was still present – but it did reduce about 30% of the pain in about 60% of the participants.
The first chronic fatigue syndrome (ME/CFS) study – a retrospective study assessing the charts of 218 patients – found that about half the participants experienced some improvement in at least two more symptoms. A 2019 case report also fleshed out the experiences of three ME/CFS patients. Recently, an Australian laboratory study suggested that LDN may help with the natural killer cell problems found in ME/CFS.
Larger studies that assess the effects of different doses and different dose protocols and more fully fill out LDN’s effects are greatly needed and Jared Younger’s Neuroinflammation, Fatigue and Pain Lab at the University of Alabama at Birmingham has a variety of LDN studies planned. The NIH, unfortunately, though, recently rebuffed Younger’s efforts to fund an ME/CFS trial featuring a potentially more potent form of LDN called dextro-naltrexone (see below).
Chronic Fatigue Syndrome/Fibromyalgia Doctors Report
“I want to make a plug for Low Dose Naltrexone” Dr. Nancy Klimas – Simmaron Research Foundation Roundtable Meeting on ME/CFS.
- Dr. Nancy Klimas reports that LDN is her first-line treatment for the pain in fibromyalgia and chronic fatigue syndrome. She’s found the drug to be effective and safe.
- Dr. Ginerva Liptan finds that LDN works in about 60% of her FM patients.
- Dr. Bela Chheda reported that she tries LDN in almost all her patients. Even when her patients do not respond she tends to keep them on for its beneficial immune effects.
Getting Low Dose Naltrexone
The preliminary evidence continues to show that low-dose naltrexone has a specific and clinically beneficial impact on fibromyalgia pain. The medication is widely available, inexpensive, safe, and well-tolerated. (Younger et. al.)
LDN, a compounded drug, is, fortunately, relatively cheap and easy to get. The biggest hurdle many patients may face is getting a prescription from a doctor unfamiliar with the drug. You might want to check out the “Starting the Conversation” chapter in The LDN Book for advice on how to enroll your doctor in writing a prescription for you. Or you could find a doctor who may prescribe it for you.
- Find doctors that prescribe LDN here, here, and here.
- Find pharmacies that compound LDN here and here. LDN Science asserts many compounding pharmacies are not reliable. They provide a list of 7 pharmacies they consider reliable here. They recommend that LDN not be used in its ‘slow-release’ form and that calcium carbonate not be used. Avicel, lactose, and sucrose fillers work fine.
- Immune Therapeutics – the drug manufacturer licensed to market LDN drugs – partnered with KRS Biotechnologies in Jan. 2015 to produce a standardized version of LDN for sale to the public and clinical trials. Costs for this high-quality, but higher-cost source of LDN are $1 a tablet. Find more about this here.
Dr. Neil Beck reported:
“People vary so much in their condition, body mass, absorption, sensitivity to and excretion of naltrexone that a doctor can only generalize about dose sizes and then you have to find out for yourself depending on how you feel and perform, your blood tests and your physical examinations and scans. What’s best for other people may not be best for you”.
Most people probably start with 1.5 mg/day and increase over a couple of weeks or a month. Skip Lenz, a well-known compound pharmacist recommends starting at 1.5 mg/day for 30 days, then go 3.0 mg for 30 days, and then re-evaluate with your doctor to determine if you should move up to 4.5 mg/day
Dr. De Meirleir, an ME/CFS specialist, reports that starting doses in ME/CFS can be as low as 0.5 mg/day and end up being 5 mg/day or more. In general, he finds that 1.5 mg. isn’t enough and 6 mg/day is too much, and that most people end up taking from 3-4.5 mg/day. He suggests that patients decrease and then increase their dose every few months to check that their requirements for the drug haven’t changed.
Some patients start off at even lower doses (.25 mg/day), and some respond positively to much higher doses of the drug. One formerly bedridden woman who received mild benefits from the drug at 3 mg/day reported that she fully recovered from ME/CFS while taking 12 mg/day.
Adjustment to the drug can take more time than expected as well. The woman who ended up taking 12mgs/day of the drug at first topped out at 3 mg but months later was able to significantly increase her dosage without incident.
New, Cheaper Way to Take LDN
Dr. Arseneau reported that a new study which indicated that naltrexone is stable in liquid makes it possible to put a 50 mg tablet into 50 ml liquid and use a 1 or 5 mg syringe to titrate it (starting at 0.5 – 1 – 1.5, etc. all the way up potentially to 4.5 mg). Theoretically, you can get to very low doses – like .1 mg or even lower using this approach. Three naltrexone tablets cost $30 making it affordable for many but the real punch line comes in the fact that while low-dose naltrexone is not covered by insurance – naltrexone is.
How Long To Take LDN To Know If It’s Working?
Longer than you may think; Jarred Younger Ph.D. stated that it can take 8-10 weeks to determine if you will respond to the drug. Don’t stop taking it before then.
Stay Away from Internet Purchases
Skip Lenz, pharmacist, reported he assayed naltrexone from six different sites on the internet, and not one passed the U.S. Pharmacopeia standards.
The Opioid Crunch
If you’re on narcotic pain drugs, do not take LDN until the drugs are out of your system. Many people with FM on opioid painkillers are, therefore, precluded from taking the drug.
Skip Lenz, a pharmacist, however, (who does not consider tramadol an opiate), stated that he has not found that doses in the range of 50 mg. taken 2-3 times a day, cause problems with LDN.
If surgery is coming up Lenz recommends being off LDN for seven days prior to your surgery. He recommends trying tramadol after the surgery.
Possible Side Effects
Side effects are usually reported to be minimal but some patients can have a great deal of difficulty with this drug. By starting the dosage off low and going slow many patients can tolerate dosages that would otherwise be intolerable.
Side effects can include sleep dysfunction (insomnia, wild dreams) and more rarely things like priapism (prolonged erections) and weight loss. In general side effects are described as ‘mild’ with few issues occurring so long as the dose begins low and is slowly titrated upwards.
Skip Lenz, a pharmacist, reported in The LDN Book that a survey of over 1000 people found that about 8% reported disturbed sleep, but except for one person the sleep issue disappeared within two weeks. All other side effects were found in less than 1% of the survey takers.
Dextro-Naltrexone – The Next Naltrexone?
Jarred Younger believes a better, possibly much, much better form of naltrexone called dextro-naltrexone may exist. Dextro-naltrexone is a different form of naltrexone that may be more effective at reducing neuroinflammation and produces fewer side effects. Younger found a source of dextro-naltrexone but failed to get funding from the National Institutes of Health for the trial.
Health Rising LDN Blogs
- Does Low Dose Naltrexone Improve Natural Killer Cell Functioning in ME/CFS?
- The Strangeness of Low Dose Naltrexone: Weird Dosing, Backward Protocols and Rejections – in ME/CFS and Fibromyalgia
- A Better Naltrexone? Jarred Younger to Study Potentially Much More Effective Dextro-Naltrexone
- Dr. Liptan on Low Dose Naltrexone’s Effectiveness in Fibromyalgia and the “Opiate LDN Quagmire”
- An Immune Disease? LDN Trial Suggests Fibromyalgia Has Inflammatory Side
- Low Dose Naltrexone Drug Combination Proposed for Chronic Fatigue Syndrome (ME/CFS)
- Finally Found – A Natural Killer Cell Enhancer for ME/CFS?
- Pharmaceutical Grade” Low Dose Naltrexone Now Available for ME/CFS and Fibromyalgia Patients
- Low’ Dose Naltrexone, Inflammation and Pain: A Different Approach to Fibromyalgia
- Successful Low Dose Naltrexone Fibromyalgia Trial Points to Safe, Low Cost Therapy; Implications for Chronic Fatigue Syndrome
- Low Dose Naltrexone Becoming ‘Standard Treatment’ for Chronic Fatigue Syndrome and Fibromyalgia
An impressive grassroots effort has sprung up on the web around LDN:
- LDN Research Trust – lots of information plus videos, doctors’ lists, forums, LDN radio, conferences, Facebook site, and more.
- Low-dose Naltrexone (LDN) for chronic illness & infections – biggest and most active Facebook site.
- Got Endorphins? LDN (Low Dose Naltrexone) – another LDN Facebook site.
- LDN Science – a science-based website with information plus patient stories, doctor lists, a preferred pharmacy, interviews with experts, etc.
- LDN World Database – features, yes, a great deal of data on LDN.
- The LDN Book – from the LDN Research Trust.
- Maija Haavisto’s LDN webpage is loaded with information and resources
- Documentary video on LDN
- The Promise of Low Dose Naltrexone – medical reference book on LDN
- Low Dose Naltrexone Website