Talk about an oddball drug. Named after the earth smoke plant, dimethyl fumarate is an old compound used in industrial chemistry. Wikipedia reported that in 2012 you could get it for from $1 to $50 per metric ton (but you had to buy at least two tons of it)....
Chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) produce so many symptoms that diagnosing them can be difficult for uninformed doctors. While we know that small fiber polyneuropathy (SFPN) (or small fiber neuropathy (SFN) commonly occurs in both these diseases,...
Sustained Stimulation of β2- and β3-adrenergic Receptors Leads to Persistent Functional Pain and Neuroinflammation. Xin Zhang, MD, PhD, Jane E. Hartung PhD, […], and Andrea G. Nackley PhD, PhD. Brain Behav Immun 2018 Oct;73:520-532. doi:...
The neuroinflammation findings in chronic fatigue syndrome (ME/CFS) and fibromyalagia (FM), while restricted to a few studies, are still pretty compelling. We know that many, if not all of the symptoms associated with ME/CFS and FM such as fatigue, pain, cognitive...
Still at the Beginning? A recent review “Current and Emerging Pharmacotherapy for Fibromyalgia” examined the state of drug therapy for FM. It was a bluntly honest review. The news on the drug side has not been, after all, all that good in FM. A large study...
Two ME/CFS, yes, ME/CFS low dose naltrexone papers appear, one fibromyalgia report attempts to turn dosing protocols on their head, one patient blows through normal dose levels with spectacular success, Jarred Younger hunts for a more powerful naltrexone, and then...
