by Cort Johnson | Jun 25, 2026 | Brain, Cardiovascular, Cerebral Spinal Fluid, Clotting, COVID-19, Craniocervical Instability, Endothelial Cells, Enterovirus, Epstein-Barr Virus, Gut, Homepage, Immune, Leaky gut, Natural Killer Cells, Neuroinflammation, Neutrophils, Pathogens, Research, Spine, T-cells
Geoff’s Narration The GIST Personal Update A Big Crash – I always feel compelled to explain what happened when the blogs suddenly stop for an extended time. This time it was a self-inflicted injury – which is a good thing, really. I am usually...
by Cort Johnson | Jun 17, 2026 | Astrocytes, Autonomic Nervous System, Biomarker, Brain, Brainstem, Cerebral Spinal Fluid, Cerebral Spinal Fluid Leaks, COVID-19, Craniocervical Instability, Gut, Homepage, Leaky gut, Neuroinflammation, Research, Spine, vagus nerve
Geoff’s Narration The GIST The 2026 PolyBio Spring Symposium – Pt I One way to gauge the health of a field is by the number of conferences/symposia it supports. From the looks of things, the long–COVID and ME/CFS fields are moving up: The...
by Cort Johnson | Apr 21, 2026 | Amytriptyline, Antivirals, CoQ10, COVID-19, Homepage, Inflammation, Ivabradine, Klimas, Lipids, long COVID, Mast cell activation syndrome, Microbiome, Orthostatic intolerance, Paxlovid, POTS, Treatment
Only 10 major long COVID clinical trials have been published thus far but that's enough to come away with some interesting takeaways. They include treatments that prevent long COVID don't necessarily treat it, broader based treatments are probably best, manipulating the gut can help with fatigue (but only so much), and an as yet unassessed class of drugs may be helpful.
by Cort Johnson | Apr 14, 2026 | Autonomic Nervous System, Brain, Brainstem, Cardiovascular, Cerebral Spinal Fluid, Clotting, Complement, Connective Tissues, Endothelial Cells, Energy Production, Gut, Homepage, Immune, Mast cell activation syndrome, Metabolism, Microbiome, Neuroinflammation, Neuroinflammation, Neutrophils, POTS, Proteomics, T-cells
What happens when you throw ten or so very different ME/CFS studies together? You get some core themes popping out. Check out the blog and see what they are.
by Cort Johnson | Nov 3, 2025 | COVID-19, Dempsey, Epstein-Barr Virus, GLP-1, Gut, Homepage, Immune, Inflammation, Kaufman, Mast cell activation syndrome, Mast cell activation syndrome, Neuroinflammation, Pathogens, POTS, RECOVER Initiative, Severe ME/CFS, Treatment
Complex, chronic illness experts discuss what GLP-1 agonists can and can't do in diseases like ME/CFS, long COVID, and POTS. Plus new long COVID trials.
by Cort Johnson | Sep 12, 2025 | B-cells, Connective Tissues, Cytokines, DeCodeME, Energy Production, Genetics, Gut, Homepage, Immune, Inflammation, Leaky gut, Lipids, Liver, Liver and urea cycle, ME/CFS, Metabolism, Microbiome, Oxidative Stress, Research, Serotonin, T-cells, Tryptophan
BioMapAI study suggests the gut problems in ME/CFS are driving other system malfunctions and symptoms.