by Cort Johnson | Jun 25, 2026 | Brain, Cardiovascular, Cerebral Spinal Fluid, Clotting, COVID-19, Craniocervical Instability, Endothelial Cells, Enterovirus, Epstein-Barr Virus, Gut, Homepage, Immune, Leaky gut, Natural Killer Cells, Neuroinflammation, Neutrophils, Pathogens, Research, Spine, T-cells
Personal Update A Big Crash – I always feel compelled to explain what happened when the blogs suddenly stop for an extended time. This time it was a self-inflicted injury – which is a good thing, really. I am usually very good in hot temperatures, but not...
by Cort Johnson | Jun 17, 2026 | Astrocytes, Autonomic Nervous System, Biomarker, Brain, Brainstem, Cerebral Spinal Fluid, Cerebral Spinal Fluid Leaks, COVID-19, Craniocervical Instability, Gut, Homepage, Leaky gut, Neuroinflammation, Research, Spine, vagus nerve
Geoff’s Narration The GIST The 2026 PolyBio Spring Symposium – Pt I One way to gauge the health of a field is by the number of conferences/symposia it supports. From the looks of things, the long–COVID and ME/CFS fields are moving up: The...
by Cort Johnson | Jun 9, 2026 | Enterovirus, Epstein-Barr Virus, Gut Infection, Homepage, Human Herpes Virus Six (HHV-6), Immune, long COVID, Lyme Disease (Borrelia), Metabolism, Pathogens, Research, T-cells
Dr. Selin and company believe they can solve one of the key mysteries of ME/CFS and long COVID: exactly why the T-cells are getting pummeled.
by Cort Johnson | Apr 21, 2026 | Amytriptyline, Antivirals, CoQ10, COVID-19, Homepage, Inflammation, Ivabradine, Klimas, Lipids, long COVID, Mast cell activation syndrome, Microbiome, Orthostatic intolerance, Paxlovid, POTS, Treatment
Only 10 major long COVID clinical trials have been published thus far but that's enough to come away with some interesting takeaways. They include treatments that prevent long COVID don't necessarily treat it, broader based treatments are probably best, manipulating the gut can help with fatigue (but only so much), and an as yet unassessed class of drugs may be helpful.
by Cort Johnson | Mar 5, 2026 | Baricitinib, Cardiovascular, Clotting, Complement, COVID-19, Endothelial Cells, Energy Production, Homepage, Hypoxia, Inflammation, Klimas, long COVID, Metabolism, Muscles, Oxidative Stress, Proteomics
The big IMPACC long COVID study findings suggest that inflammation and reduced male sex hormone levels may be playing havoc with the small blood vessels in long COVID -= and ME/CFS
by Cort Johnson | Dec 17, 2025 | Complement, COVID-19, Cytokines, Drugs, Homepage, Immune, Inflammation, Interferons, JAK_STAT Inhibitors, Metabolism, Monocytes, Natural Killer Cells, Oxidative Stress, Pathogens, Research, T-cells, Treatment
Harvard researchers find an activated and exhausted immune system in long COVID patients - and begin a drug trial to try to fix it.